BRAIN BEHAVIOR AND IMMUNITY

Intranasal bFGF‑Els alleviate doxorubicin‑induced cognitive deficits in mice by modulating the PI3K/AKT pathway and suppressing oxidative stress, neuroinflammation, and apoptosis

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Ming Zhang, Wen-yue He, Wei-cheng Ma, Shu-fang Yu

Omega-3 fatty acids, specialized pro-resolving mediators, and depression: A mechanistic meta-analysis of precursors and clinical implications

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Ayesha Zafar Iqbal, Aimal Khan, Ikbal Andrian Malau, Suet-Kei Wu, Jane Pei-Chen Chang, Chin Cheng, Ming-Jun Tsai, Fan Wang, Kuan-Pin Su

Corrigendum to “Inhibition of lysophosphatidic acid receptor 1 attenuates neuroinflammation via PGE2/EP2/NOX2 signalling and improves the outcome of intracerebral haemorrhage in mice” [Brain Behav. Immun. 91 (2021) 615–626]

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Peripheral inflammation is associated with emotional dysregulation, suicide attempts, and reduced microstructural integrity of white matter in young adults with borderline personality disorder

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Publication date: October 2026 Source: Brain, Behavior, and Immunity, Volume 137 Author(s): Giulia Quattrini, Nadia Cattane, Chiara Galbiati, Moira Marizzoni, Laura Pedrini, Mariangela Lanfredi, Roberto Gasparotti, Daniele Corbo, Giuseppe Nicolò, Antonio Semerari, Ilaria Riccardi, Michela Pievani, Antonino Carcione, Roberta Rossi, Annamaria Cattaneo, for the CLIMAMITHE Study Group

Exposure to SARS-CoV-2 Spike protein during development induces astrogliosis, synapse loss and long-term cognitive dysfunction in mice

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Publication date: Available online 12 May 2026 Source: Brain, Behavior, and Immunity Author(s): Débora M. Portela, Bruna Andrade, Emanuelle V. De Lima, Vitor Gayger-Dias, Daniel F. Messor, Larissa Daniele Bobermin, Lídia G. Paúra, Marcos Romário Matos de Souza, Sanclayver Araujo, Isadora Alonso Corrêa, Beatriz Oliveira de Campos, Vanessa-Fernanda Da Silva, Thomas Michel Sobottka, Daniele Schauren da Costa, Luiz Ricardo Berbert, Luciana J. da Costa, Carlos-Alberto Gonçalves, Leda Castilho, Renato S. Carvalho, André Quincozes-Santos

Paternal high molecular weight poly I:C administration alters the sperm small non-coding RNA profile and offspring brain development and behavioural phenotype

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Publication date: Available online 17 April 2026 Source: Brain, Behavior, and Immunity Author(s): Nicholas van de Garde, Qi Meng, Ganani Dontamsetti, Pamudika Kiridena, Da Lu, Bethany A. Masson, Pranav Adithya, Huan Liao, Sonali N. Reisinger, Anthony J. Hannan

The acute phase inflammatory response as a key determinant of reduced lipid-associated antioxidant defenses in Chinese patients with major depressive disorder

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Tangcong Chen, Mengqi Niu, Yueyang Luo, Jing Li, Abbas F. Almulla, Yingqian Zhang, Michael Maes

From neuroinflammation to synaptic rewiring: HMGB1 as a central integrator in methamphetamine addiction

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Fangmin Wang, Huizhen Liu, Chaoyang Chu, Wenhua Zhou

Therapeutic potential of a novel PPARγ agonist in a mouse model of HIV-associated neurocognitive impairment

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Celene Titus, Md. Tozammel Hoque, Robert Bonin, Reina Bendayan

Sex-associated neuroinflammatory and astrocytic responses in amyotrophic lateral sclerosis: evidence from clinical cohorts and a TDP-43 N390D mouse model

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Publication date: Available online 9 July 2026 Source: Brain, Behavior, and Immunity Author(s): Wenfei Yu, Bing Zhao, Mingjie Ma, Ninglu Gao, Yan Yun, Xiaohan Sun, Kai Shao, Pengfei Lin, Wei Li, Yuying Zhao, Dexin Yu, Cuiping Zhao, Fuchen Liu, Chuanzhu Yan, Shuangwu Liu

Perinatal antiretroviral-associated cytokine and gut microbiota outcomes in deer mouse dams and their behaviorally diverse adult offspring

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De Wet Wolmarans, Jo-Anne Stroebel, Rencia van der Sluis, Timothy R Sampson, Heather B Jaspan, Anna-Ursula Happel

Alterations in varicella-zoster virus immunity around dementia diagnosis in older adults

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Christoffer Granvik, Johan Normark, Anders F. Johansson, Mattias N.E. Forsell, Preeti Moar, for the Säbo study group

Authentic artworks or real environments? Implications of real-world experiences for the neuroimmune system

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Publication date: October 2026 Source: Brain, Behavior, and Immunity, Volume 137 Author(s): Laura Nataly Panqueva Giraldo, John Leonardo Torres Castiblanco, David Fernando Torres Cortes

Brain endothelial tmTNFα overexpression in a mouse model altered cell type-specific signaling changes linked to schizophrenia-relevant behaviors

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Publication date: August 2026 Source: Brain, Behavior, and Immunity, Volume 136 Author(s): Jun Sang Yu, Minji Kim, Jaesuk Yun, Seong Hee Jeon, Dong Ju Son, Sang-Bae Han, Maree J. Webster, Lydia Kim, Jin Tae Hong, In Jun Yeo, Sanghyeon Kim

Omega-3 fatty acids, specialized pro-resolving mediators, and depression: A mechanistic meta-analysis of precursors and clinical implications

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Ayesha Zafar Iqbal, Aimal Khan, Ikbal Andrian Malau, Suet-Kei Wu, Jane Pei-Chen Chang, Chin Cheng, Ming-Jun Tsai, Fan Wang, Kuan-Pin Su

Neuroinflammation as a driver of Down syndrome-associated Alzheimer’s disease

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The Physiological Impact of Viewing Original Artworks in a gallery vs. Reproductions in a laboratory: A Comparative Study

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Publication date: Available online 1 May 2026 Source: Brain, Behavior, and Immunity Author(s): Courtney Worrell, Madeline Kirkpatrick, Camila Ribeiro Perez, Sorcha Alford, Pierette Fortuna, Leyla Bumbra, Lucy Bradnock, Anthony J. Woods

Additive effects of anxiety/depression and transportation noise exposure on cardiovascular risk and measures of neural-immune mechanisms

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Fatima Saeed, Krystel AbiKaram, Shady Abohashem, Joseph D. Nguyen, Maximilian Mathias, Omar Abduljaleel, Mahmoud Abdou Awad Elsayed, Abdulrahman Ahmed Al-Bazaz, Midori N. Torpoco-Rivera, Emamuzo O. Otobo, Alula Assefa, Annmarie Khawand, Sinead M. Sinnott, Jamie L. Banks, Antonia V. Seligowski, Thomas Muenzel, Ahmed A. Tawakol, Michael T. Osborne

A psychometric evaluation of diffusion basis spectrum imaging indicates altered white matter microstructure consistent with elevated edema in depression

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Luisa Kaluza, Anne Kühnel, Ekaterina Kuskova, Kim Studener, Denise Rommel, Jana Lieberz, Nils B. Kroemer

Insomnia and inflammatory exposure impair spatial memory and cognitive mapping in older adults: a randomized controlled trial

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Publication date: October 2026 Source: Brain, Behavior, and Immunity, Volume 137 Author(s): Dominique Piber, Richard Olmstead, Joshua Hyong-Jin Cho, Nina Sadeghi, Daisy Castillo, Haesoo Kim, Michael R. Irwin

PD-1/PD-L1 signaling in neurological and psychiatric disorders: neuroimmune mechanisms and therapeutic potential

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Xiangning Chen, Xingjun Wang, Chengwei Li, Kaiyue Shan, Lezhen Wang, Kenji Hashimoto, Kai Shao, Penghui Wei, Jian-jun Yang

An interfering peptide attenuates diabetic encephalopathy by blocking the interaction between CD44 and STAT3

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Publication date: August 2026 Source: Brain, Behavior, and Immunity, Volume 136 Author(s): Chengyu Huang, Qiuyu Zhang, Xi Wang, Yanjie Xie, Yanmeng Zhou, Chunjing Yan, Kunyang Wang, Hongyu Zhu, Lin Gao, Shidi Wu, Hui Li, Aifang Cheng, Bin Hu, Xiaoyan Zhou, Changjiang Ying

The Price of Protection: Evolutionary tradeoffs in inflammatory depression

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Publication date: August 2026 Source: Brain, Behavior, and Immunity, Volume 136 Author(s): Abhay Bindroo, Jonathan Savitz

A critical in vivo role for microglial p38α MAPK in HIV-1 associated inflammatory brain injury

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Deepika Bhullar, Ricky Maung, Amanda J. Roberts, Rabi Murad, Monica J. Carson, Marcus Kaul

Intranasal bFGF‑Els alleviate doxorubicin‑induced cognitive deficits in mice by modulating the PI3K/AKT pathway and suppressing oxidative stress, neuroinflammation, and apoptosis

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Ming Zhang, Wen-yue He, Wei-cheng Ma, Shu-fang Yu

Higher polygenic scores for C-reactive protein is associated with lower striatal reward magnitude coding in early adolescents

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Lily A. Heritage, Iris Ka-Yi Chat, Jonathan Ahern, Robert J. Loughnan, Robin L. Aupperle, Chun Chieh Fan, Martin P. Paulus, Wesley K. Thompson, Haixia Zheng

Age, Stress, and markers of inflammation among middle-aged to older African American Adults: Findings from The Heart of Detroit study

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Childhood immunomodulatory biomarkers and risk of depression and psychosis-spectrum outcomes at age 24: longitudinal evidence from the ALSPAC birth cohort

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Publication date: October 2026 Source: Brain, Behavior, and Immunity, Volume 137 Author(s): Lorenzo Ghelfi, David Mongan, Jennifer Murphy, Lorna Staines, Colm Healy, Subash Raj Susai, Golam M. Khandaker, Mary Cannon, David R. Cotter

A longitudinal analysis of bidirectional relationships between executive functioning and peripheral inflammation in schizophrenia

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Publication date: August 2026 Source: Brain, Behavior, and Immunity, Volume 136 Author(s): Angelina Van Dyne, Tsung-Chin Wu, David H. Adamowicz, Michael R. Irwin, Xin M. Tu, Ellen E. Lee, Lisa T. Eyler

Maternal granulocyte colony-stimulating factor alters synaptic maturation and social behaviors in offspring

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