2026-10-22
Dina Y. Bass, Ekaterina S. Potekhina, Alexander V. Ivanenko, Aleksandr A. Moshchenko, Dmitry A. Korzhenevskiy, Alexey M. Nesterenko, Evgeny K. Shevchenko, Anastasia E. Karnaeva, Natalia F. Zakirova, Alexander V. Ivanov, Liubov E. Shimolina, Marina V. Shirmanova, Olga V. Lyang, Olga I. Patsap, Olga M. Kudryashova, Guzel R. Gazizova, Elena I. Shagimardanova, Sofia S. Mariasina, Vasiliy A. Ivlev, Ivan Bogeski, Oleg A. Gusev, Vsevolod V. Belousov
The chemogenetic tool Grubraw activates mitochondria by generating pyruvate in the mitochondrial matrix. This triggers a genetic switch that slows down tumor cell proliferation. Tumor cells counteract this by exporting excess pyruvate outward.
DOI: 10.1038/s41589-026-02350-72026-10-22
Valentin Cracan
Pyruvate links glycolysis to mitochondrial oxidative metabolism, while the Warburg effect diverts it to lactate. A xenotopic chemogenetic tool based on bacterial d-alanine dehydrogenase generates pyruvate in the mitochondrial matrix independently of glycolysis, resulting in enhanced respiration and pyruvate export.
DOI: 10.1038/s41589-026-02343-62026-10-19
Irene Serrano
DOI: 10.1038/s41589-026-02360-52026-10-19
Gene Chong
DOI: 10.1038/s41589-026-02361-42026-10-19
Francesco Zamberlan
DOI: 10.1038/s41589-026-02365-02026-10-19
Huijuan Guo
DOI: 10.1038/s41589-026-02363-22026-10-19
Russell Johnson
DOI: 10.1038/s41589-026-02362-32026-10-19
Grant Miura
DOI: 10.1038/s41589-026-02364-12026-03-27
Yuan-Ting Cho, Jeremy M. Baskin
Nature Chemical Biology, Published online: 27 March 2026; doi:10.1038/s41589-026-02184-3 By combining targetable, cell-permeable photosensitizers with amine-based electrophilic trapping chemistry, a technology termed singlet-oxygen-based photocatalytic proximity labeling (POCA) provides a general strategy for profiling the protein interactomes of diverse molecular baits, including cholesterol, in their native cellular environments.
2026-03-24
Takaaki Akaike, Beatriz Alvarez, Ruma Banerjee, Clive Yik-Sham Chung, Tobias P. Dick, Cristina Furdui, Mark Hampton, Elena Hidalgo, Gerta Hoxhaj, Carola Neumann, Pablo Rivera-Fuentes, Eranthie Weerapana, Ming Xian
Nature Chemical Biology, Published online: 24 March 2026; doi:10.1038/s41589-026-02178-1 We asked a collection of redox biologists, “What do you think are the most exciting frontiers or the most needed developments in redox biology?” — here is what they said.