Singlet oxygen spills sterol secrets
2026-03-27
Yuan-Ting Cho, Jeremy M. Baskin
Nature Chemical Biology, Published online: 27 March 2026; doi:10.1038/s41589-026-02184-3 By combining targetable, cell-permeable photosensitizers with amine-based electrophilic trapping chemistry, a technology termed singlet-oxygen-based photocatalytic proximity labeling (POCA) provides a general strategy for profiling the protein interactomes of diverse molecular baits, including cholesterol, in their native cellular environments.