2026-09-18
Xueyi Zheng, Ke Zheng, Jue Wang, Xinke Zhang, Kai Li, Zihan Zhao, Chaofeng Li, Haohua Chen, Ruixuan Wang, Junpeng Lai, Bing Chu, Sha Fu, Dan Xie, Muyan Cai
Zheng, Zheng, Wang, Zhang et al. developed CROWN, a universal visual foundation model for cytopathology, which they benchmarked on more than 200 real-world cytology tasks across cohorts, including lymph node metastasis and cervical screening datasets.
DOI: 10.1038/s43018-026-01240-02026-09-16
Heathcliff Dorado García
DOI: 10.1038/s43018-026-01246-82026-09-15
Julieta Afonso
DOI: 10.1038/s43018-026-01245-92026-09-14
We identified a metabolic signaling axis that enables pancreatic cancer cells to survive chemotherapy by suppressing ferroptosis. Targeting of the valine catabolism enzyme MMSDH reverses this chemoresistance and shows promise as a potential component of combination strategies against refractory tumors.
DOI: 10.1038/s43018-026-01235-x2026-09-14
Silvia Marsoni, Clara Montagut, Filippo Pietrantonio, Andrea Sartore-Bianchi, Luca Lazzari, Francesca Bergamo, Maria Giulia Zampino, Noelia Tarazona, Mario Mandalà, Stefano Tamberi, Elena Elez, Cristina Santos Vivas, Paolo Luraghi, Michele Prisciandaro, Federica Tosi, Davide Ciardiello, Joana Vidal, Victor Seguì, Michele Palazzo, Giulia Maddalena, Katia Bencardino, Ida Taglialatela, Marta Guix, Eliana Rulli, Valentina Vettore, Federica Morano, Claudio Isella, Giovanni Crisafulli, Giorgio Patelli, Enzo Medico, Alberto Bardelli, Andrés Cervantes, Valter Torri, Josep Tabernero, Salvatore Siena, Sara Lonardi
Marsoni et al. evaluated the feasibility of a dynamic circulating tumor DNA-guided adjuvant and postadjuvant treatment strategy in patients with resected microsatellite-stable, high-risk stage II or III colon cancer in the phase 2 PEGASUS trial.
DOI: 10.1038/s43018-026-01237-92026-09-11
Peixiang Zheng, Yanni Lin, Meiyin Zhang, Zhiyuan Tang, Wenxing Qin, Min Xiao, Xue Sun, Yuli Shen, Zhiqiang Hu, Shuo Ru, Yuran Duan, Bofei Dong, Ting Wen, Mengdie Li, Hong Wu, Yueru Hou, Guimei Ji, Zheng Wang, Xiaohong Wu, Qimin Zhou, Xiaoguang Liu, Gaopeng Li, Yuhao Wang, Shengzhong Duan, Yang Luo, Bo Chu, Xu Qian, Zhimin Lu, Yuan Ding, Chuan Xu, Tong Liu, Daqian Xu
Zheng et al. describe how hypoxia-induced methylmalonate semialdehyde dehydrogenase lactylation promotes acyl-CoA synthetase long-chain family member 4 propionylation and degradation, thereby suppressing ferroptosis induced by chemotherapy, and develop a blocking peptide that increased chemotherapy efficacy in pancreatic ductal adenocarcinoma.
DOI: 10.1038/s43018-026-01236-w2026-09-09
Ping Lai, Lei Liu, Nicolò Pernigoni, Yingxi Du, Daniele Braga, Martina Troiani, Giuseppe Attanasio, Yuxin Li, Pan Song, Emiliano Pasquini, Tanja Rezzonico Jost, Xiaowen Huang, Martino Maddalena, Simone Mosole, Andrea Rinaldi, Giovanna Pecoraro, Martino Pedrani, Aurora Valdata, Nicolò Bancaro, Luisa Maraccani, Alessandra De Giani, Wei Yuan, Lewis Gallagher, Khobe Chandran, Penny Flohr, Pasquale Rescigno, Giuseppe Reitano, Alessandro Morlacco, Fabrizio Dal Moro, Isabella Giacomini, Monica Montopoli, Matteo Brunelli, Serena Pedron, Ricardo Pereira Mestre, Raad Z. Gharaibeh, Christian Jobin, Silke Gillessen Sommer, Johann de Bono, Andrea Alimonti
Lai et al. show that Nakaseomyces glabratus is enriched in fecal and tumor samples of patients with castration-resistant prostate cancer and that administration of the fungus accelerates cancer progression in prostate cancer-bearing castrated mice.
DOI: 10.1038/s43018-026-01229-92026-09-01
The addition of oral l-glutamine to first-line gemcitabine plus nab-paclitaxel appears safe and is associated with improved survival outcomes and tumor responses compared with historical benchmarks in untreated advanced pancreatic cancer. The beneficial effects of l-glutamine may be mediated through modulation of intermediary metabolism, gut microbial function, inflammatory responses and gut barrier integrity.
DOI: 10.1038/s43018-026-01231-1