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22 parsed articles
Last update: 2026-09-22
2026-09-16
Stephen M. Fleming
The capacity to self-evaluate and control one’s own cognitive performance, known as metacognition, underpins adaptive learning, social behaviours and self-belief. Stephen Fleming outlines our current understanding of the neural basis of metacognition, its contributions to self-regulation and social communication, and the consequences of its dysfunction in clinical conditions.
DOI: 10.1038/s41583-026-01081-x2026-09-14
Yu Qi
In this Journal Club, Yu Qi discusses a 2021 study that reported a brain–computer interface that used neural activity in the motor cortex to decode attempted handwriting in real time.
DOI: 10.1038/s41583-026-01082-w2026-09-11
Jeremy S. Biane, Julian Wagner-Carena, Mazen A. Kheirbek
Recent years have witnessed major advances in our understanding of the distinct functional and computational roles of the ventral hippocampus (vHPC). Mazen Kheirbek and colleagues examine the state-dependent representation of behaviourally salient information by the vHPC and discuss how its anatomy and circuit connectivity support affective and motivational behaviours.
DOI: 10.1038/s41583-026-01078-62026-09-11
Alberto E. Pereda, Adam C. Miller
The mechanisms underlying electrical transmission are often viewed as relatively simple compared with those mediating chemical transmission, yet electrical synapses exhibit dynamic changes in structure and strength. In this Review, Alberto Pereda and Adam Miller examine the structural and molecular bases and complexities of electrical transmission.
DOI: 10.1038/s41583-026-01080-y2026-08-28
Darran Yates
A new study reports that olfactory receptor genes in the mosquito Aedes aegypti can be coexpressed in olfactory neurons and expressed in multiple subtypes of these neurons.
DOI: 10.1038/s41583-026-01077-72026-08-28
Tal Golan, Heiko H. Schütt, Nikolaus Kriegeskorte
Neural network models can express computational hypotheses about brain information processing, but their high parametric capacity makes discriminating model alignment to experimental data challenging. In this Review, Kriegeskorte and colleagues discuss methodology for the optimization of stimuli that make models disagree in their predictions of neural and behavioural data and enhance model comparison.
DOI: 10.1038/s41583-026-01070-02026-08-27
Jake Rogers
Humans learn the extent to which outcomes are causally attributable to performance through dorsomedial prefrontal cortex tracking decision confidence to estimate the level of control in an environment as well as controllability changes via its interactions with the dorsal raphe nucleus.
DOI: 10.1038/s41583-026-01076-82026-08-27
Sian Lewis
Injury to hand nerves can lead to disordered digit representation, which is now shown to arise as a result of altered peripheral inputs following nerve regeneration.
DOI: 10.1038/s41583-026-01079-52026-07-07
Sian Lewis
Nature Reviews Neuroscience, Published online: 07 July 2026; doi:10.1038/s41583-026-01069-7 Training on brain–computer interfaces is shown to be markedly improved by using real-time reinforcement feedback instead of relying only on sensory feedback, which can be impaired in users of these devices.]]>
DOI: 10.1038/s41583-026-01069-72026-07-03
Stephan Pohl
Nature Reviews Neuroscience, Published online: 03 July 2026; doi:10.1038/s41583-026-01063-z Reply to ‘Boundary issues for multidimensional frameworks of representation’]]>
DOI: 10.1038/s41583-026-01063-z2026-06-23
Vanessa H. Casha
Nature Reviews Neuroscience, Published online: 23 June 2026; doi:10.1038/s41583-026-01054-0 Recent technological advances have provided novel understanding of the spatiotemporal relationship between gene expression and protein levels. In this Review, Khakh and colleagues summarize recent work on astrocyte proteomes and subproteomes, emphasizing methodological breakthroughs and new biological insights relevant to fundamental astrocyte biology in neural circuits.]]>
DOI: 10.1038/s41583-026-01054-02026-06-12
Derek Bowie
Nature Reviews Neuroscience, Published online: 12 June 2026; doi:10.1038/s41583-026-01055-z AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain. Derek Bowie and colleagues describe recent advances in our understanding of the regulatory layers that operate across the lifespan of an AMPAR to govern its assembly, structure and function.]]>
DOI: 10.1038/s41583-026-01055-z2026-06-02
Renata Batista-Brito
Nature Reviews Neuroscience, Published online: 02 June 2026; doi:10.1038/s41583-026-01051-3 In this Journal Club, Renata Batista-Brito discusses a 2009 study that showed that a population of inhibitory hub neurons orchestrate network synchrony in the developing hippocampus.]]>
DOI: 10.1038/s41583-026-01051-32026-05-21
Sian Lewis
Nature Reviews Neuroscience, Published online: 21 May 2026; doi:10.1038/s41583-026-01053-1 Neuronal loss in a mouse model of Alzheimer disease occurs through necroptosis and is shown to be dependent on low-glucose conditions, which increase hyperphosphorylated tau levels; in turn, this simultaneously activates pro-necroptotic pathways and disables a key checkpoint mechanism.]]>
DOI: 10.1038/s41583-026-01053-12026-05-12
Katherine Whalley
Nature Reviews Neuroscience, Published online: 12 May 2026; doi:10.1038/s41583-026-01050-4 Two studies use single-nucleus multiomic sequencing to profile molecular and cellular dysfunction in the prenatal and early postnatal cortex in Down syndrome.]]>
DOI: 10.1038/s41583-026-01050-42026-05-11
Michael Lohse
Nature Reviews Neuroscience, Published online: 11 May 2026; doi:10.1038/s41583-026-01045-1 The auditory system differs from other senses in the complexity of its subcortical pathways. King and colleagues examine how subcortical structures transform sound representations and integrate sensory and behavioural context, highlighting their fundamental role in shaping cortical activity and in active listening.]]>
DOI: 10.1038/s41583-026-01045-12026-04-27
Baolin Guo
Nature Reviews Neuroscience, Published online: 27 April 2026; doi:10.1038/s41583-026-01048-y In this Journal Club, Baolin Guo highlights a 2011 study that linked altered excitation–inhibition balance in prefrontal circuits to social dysfunction in mice.]]>
DOI: 10.1038/s41583-026-01048-y2026-04-15
Hao Li
Nature Reviews Neuroscience, Published online: 15 April 2026; doi:10.1038/s41583-026-01044-2 In this Tools of the Trade article, Hao Li describes the development of a mesoscale optogenetics platform for targeted and precise stimulation of the primate cortex.]]>
DOI: 10.1038/s41583-026-01044-22026-04-07
Sian Lewis
Nature Reviews Neuroscience, Published online: 07 April 2026; doi:10.1038/s41583-026-01043-3 Perturbing female Drosophila behaviour during courtship induces adaptive changes in innate male fly courtship song patterns; these changes are initially retained in subsequent courtship encounters with normal female behaviour, but songs gradually return to innate patterns.]]>
DOI: 10.1038/s41583-026-01043-32026-03-26
Maria V. Sanchez-Mico, Maria Calvo-Rodriguez, Brian J. Bacskai
Nature Reviews Neuroscience, Published online: 26 March 2026; doi:10.1038/s41583-026-01032-6 Astrocytic Ca2+ signalling is a fundamental and highly spatiotemporally nuanced mechanism for maintaining brain homeostasis. In this Review, Bacskai and colleagues discuss how astrocytic Ca2+ homeostasis is altered in ageing and neurodegenerative diseases and plays a central role in neurodegenerative pathophysiology.
2026-03-18
Darran Yates
Nature Reviews Neuroscience, Published online: 18 March 2026; doi:10.1038/s41583-026-01037-1 A new study in mice reveals a neuron–epithelial cell circuit in the intestine that promotes type 2 immunity.
2026-03-04
Jake Rogers
Nature Reviews Neuroscience, Published online: 04 March 2026; doi:10.1038/s41583-026-01033-5 Dorsal medial prefrontal cortex simultaneously yet independently encodes interconnected attributes of environmental cues to motivate appetitive and aversive behaviour in mice via multifaceted representations.