2020-08-09
Silva Filho, José Damião da, Ramos Júnior, Alberto Novaes, Pinheiro, Marta Cristhiany Cunha, Silva, Bárbara Morgana da, Ferreira, Anderson Fuentes, Sousa, Maria Aparecida Alexandre de, Gomes, Vivian da Silva, García, Gabriela Soledad Márdero, Bezerra, Fernando Schemelzer de Moraes
Silva Filho, José Damião Da ; Ramos Júnior, Alberto Novaes ; Pinheiro, Marta Cristhiany Cunha ; Silva, Bárbara Morgana Da ; Ferreira, Anderson Fuentes ; Sousa, Maria Aparecida Alexandre De ; Gomes, Vivian Da Silva ; García, Gabriela Soledad Márdero ; Bezerra, Fernando Schemelzer De Moraes ; ABSTRACT Background: The São Francisco River Integration Project (PISF) may facilitate the spread of intermediate hosts of schistosomiasis to previously unaffected areas, potentially increasing disease transmission owing to human migration and environmental changes. This study aimed to describe the distribution of freshwater mollusk fauna along the river basins involved in the PISF in the state of Ceará. Methods: A descriptive cross-sectional study was conducted in three municipalities in the state of Ceará (Brejo Santo, Jati, and Mauriti) located along the Meta 2N axis of the PISF. Mollusks were collected from 21 water bodies near the resettlement areas (productive rural villages). Morphological identification of freshwater snails and screening for Schistosoma mansoni (S. mansoni) cercariae were also performed. Environmental variables were recorded, and the potential for transmission was assessed according to the Brazilian Ministry of Health guidelines. Results: Overall, 765 Biomphalaria specimens were collected, with Biomphalaria straminea being the only species identified. This genus occurred in all three municipalities and 85.7% of the surveyed water bodies. The other identified mollusk genera included Melanoides, Drepanotrema, Physa, Pomacea, and members of the class Bivalvia. No S. mansoni larvae were found, and only nonpathogenic trematode larvae were observed. Eight water bodies were classified as having a high epidemiological risk. Conclusions: The surveyed communities represent areas with the potential to sustain schistosomiasis transmission. These findings highlight the importance of developing intersectoral strategies to address the issue from a One Health perspective and to implement effective interventions in the areas impacted by the project.
2020-08-09
Santana, Hortência Aparecida dos Reis, Diamantino, Isabela Pedra, Arruda, Jean Carlos de Araújo, Silva, Pedro Alysson Mota da, Santos, Gabrieli Souza dos, Oliveira, Jonatas César Matos de, Souza, Vanessa Oliveira de, Costa, Clécio Ribeiro, Macke, Andrea Pereira, Teles, Karen Nepomuceno Sá, Vieira, Fernando do Prado, Lima, Filipe Rocha, Lima, Jonilson Berlink
Santana, Hortência Aparecida Dos Reis ; Diamantino, Isabela Pedra ; Arruda, Jean Carlos De Araújo ; Silva, Pedro Alysson Mota Da ; Santos, Gabrieli Souza Dos ; Oliveira, Jonatas César Matos De ; Souza, Vanessa Oliveira De ; Costa, Clécio Ribeiro ; Macke, Andrea Pereira ; Teles, Karen Nepomuceno Sá ; Vieira, Fernando Do Prado ; Lima, Filipe Rocha ; Lima, Jonilson Berlink ; ABSTRACT Pure neural leprosy (PNL) is infrequent and manifests exclusively in the peripheral nerves without skin involvement, making the diagnosis more complex. We report the case of a 10-year-old child with muscle atrophy and sensory loss, diagnosed through clinical evaluation, grade 2 disability, and a positive anti-PGL-I test. The slit-skin smear (SSS) was negative for acid-fast bacilli. After 12 months of multidrug therapy, esthesiometric sensitivity improved; however, neurological deficits persisted, requiring anti-inflammatory treatment and physiotherapy. This case highlights the importance of early diagnosis and treatment for preventing disabilities. Tools, such as anti-PGL-I tests and imaging, are crucial, particularly in resource-limited settings.
2020-08-09
Mançano, Alexandre Dias, Zanetti, Gláucia, Marchiori, Edson
Mançano, Alexandre Dias ; Zanetti, Gláucia ; Marchiori, Edson ;
2020-08-09
Hochhegger, Bruno, Zanetti, Gláucia, Marchiori, Edson
Hochhegger, Bruno ; Zanetti, Gláucia ; Marchiori, Edson ;
2020-08-09
Şimşek, Sadullah, Karaca, Mehmet Salih, Sağlam, Tarık
Şimşek, Sadullah ; Karaca, Mehmet Salih ; Sağlam, Tarık ;
2020-08-09
Costa, Gabriela Rodrigues de Toledo, Passos, Pedro Henrique de Oliveira, Sousa, Davi Emanuel Ribeiro de, Macêdo, Isabel Luana de, Ramos, Daniel Garkauskas, Cavalcante, Karina Ribeiro Leite Jardim, Romano, Alessandro Pecego Martins, Martins Filho, Arnaldo Jorge, Casseb, Livia Medeiros Neves, Martins, Livia Caricio, Gottdenker, Nicole Lynn, Lima, Eduardo Mauricio Mendes de, Melo, Cristiano Barros de, Castro, Márcio Botelho de
Costa, Gabriela Rodrigues De Toledo ; Passos, Pedro Henrique De Oliveira ; Sousa, Davi Emanuel Ribeiro De ; Macêdo, Isabel Luana De ; Ramos, Daniel Garkauskas ; Cavalcante, Karina Ribeiro Leite Jardim ; Romano, Alessandro Pecego Martins ; Martins Filho, Arnaldo Jorge ; Casseb, Livia Medeiros Neves ; Martins, Livia Caricio ; Gottdenker, Nicole Lynn ; Lima, Eduardo Mauricio Mendes De ; Melo, Cristiano Barros De ; Castro, Márcio Botelho De ; ABSTRACT Background: Surveillance of non-human primate (NHP) deaths is vital for the early detection of yellow fever (YF) and prevention of its spread to the human population. This study assessed the YF surveillance system for NHPs in the Brazilian Federal District (FD) from 2008 to 2022. Methods: A retrospective analysis of the aggregated data from 15 years of outbreak surveillance involving NHP deaths was conducted. The analyzed variables included spatiotemporal distribution, species, sex, age, sample collection, cause of death, and YF test results. Results: In total, 1,175 outbreaks involving 1,353 NHP deaths were recorded, averaging 1.35 animals per outbreak, in urban and peri-urban areas. Twenty YF-positive outbreaks were confirmed in 2008, 2015, and 2020, affecting 27 animals, mainly adult Callithrix spp., with an overall YF positivity rate of 2%. Surveillance coverage expanded across all administrative regions of FD, with 96.7% of NHP deaths sampled for YF and pathological analysis. Over the last 5 years, the rate of conclusive diagnoses has increased by 60%, with trauma and infectious diseases being the most common causes of death. Conclusions: The strategic location of FD reinforces the need for ongoing NHP death surveillance as an early warning tool for patients with YF. Continued enhancement of the diagnostic capacity and data integration is essential for strengthening the prevention and control efforts of YF in Brazil.
2020-08-09
Reis, Ana Júlia, Gómez, Michael Andrés Abril, Souza, Mariana Quaresma de, Vianna, Júlia Silveira, Ramis, Ivy Bastos, Silva, Pedro Eduardo Almeida da
Reis, Ana Júlia ; Gómez, Michael Andrés Abril ; Souza, Mariana Quaresma De ; Vianna, Júlia Silveira ; Ramis, Ivy Bastos ; Silva, Pedro Eduardo Almeida Da ; ABSTRACT The Mycobacterium abscessus complex (MABC) includes non-tuberculous mycobacteria that are widely distributed and clinically significant. Similar to tuberculosis, MABC can lead to skin and soft tissue infections and pulmonary diseases. These infections frequently occur in outbreaks, particularly among immunocompromised patients or those with preexisting pulmonary conditions. This review examines the recent progress in essential areas that define these infections as a significant challenge in medical practice, specifically the diagnostic modalities, antibiotic treatment options, and resistance of MABC to antibiotics and biocides.
2020-08-09
Gomes, Jorhanna Isabelle Araújo de Brito, Queiroz, Suellen Bernardo de, Barbosa, Carlos Gabriel Andrade, Silva, Larissa Rodrigues Santos, Lundgren, Patrícia Urquiza, Sousa, Eduardo Sergio Soares, Campana, Eloiza Helena, Perez, Vinicius Pietta
Gomes, Jorhanna Isabelle Araújo De Brito ; Queiroz, Suellen Bernardo De ; Barbosa, Carlos Gabriel Andrade ; Silva, Larissa Rodrigues Santos ; Lundgren, Patrícia Urquiza ; Sousa, Eduardo Sergio Soares ; Campana, Eloiza Helena ; Perez, Vinicius Pietta ; ABSTRACT Background: Streptococcus agalactiae (commonly referred to as group B streptococci [GBS]) is a leading cause of neonatal infection. Surveillance of colonization in pregnant women and the use of intrapartum antibiotic prophylaxis (IAP) are the primary strategies for preventing early-onset GBS disease. The increasing rate of antibiotic resistance among GBS isolates is a concern for the effectiveness of IAP. Our study aimed to evaluate the prevalence of GBS colonization and characterize antimicrobial resistance patterns over a five-year period in a high-risk pregnancy referral center in Northeastern Brazil. Methods: This study was conducted from 2020 to 2024 and included pregnant women at 35-37-week gestation. GBS isolates from anal-vaginal swabs were identified and tested for susceptibility to penicillin or ampicillin, clindamycin, erythromycin, levofloxacin, and tetracycline. Isolates stored from 2021 to 2024 were further analyzed for the resistance genes mef(A), erm(A/TR), erm(B), tet(M), and tet(O). Results: Of 1469 anal-vaginal samples, the overall GBS colonization rate was 12%. All isolates were susceptible to either penicillin or ampicillin. The respective resistance rates for erythromycin, clindamycin, levofloxacin, and tetracycline were 23.6%, 9.3%, 5.4%, and 82.3%. The main determinant among macrolide-resistant isolates was mef(A), and tet(M) was the most frequent tetracycline resistance gene. Furthermore, we found that erythromycin resistance increased consistently over the five years, signaling a potential impact on clindamycin efficacy due to erm genes. Conclusions: Beta-lactams (penicillin and ampicillin) remained effective for IAP in northeastern Brazil during the study period. However, high and increasing resistance to other antibiotic classes reinforces the need for maternal GBS surveillance and ongoing antimicrobial resistance monitoring.
2020-08-09
Silva, João Victor Corrêa e, Carvalho, Lethícia de Oliveira, Silva, Luiz Henrique da, Barbosa Junior, Marcos Antonio da Silva, Sousa, Pedro Vinicius Leite de, Costa, Laurisson Albuquerque da
Silva, João Victor Corrêa E ; Carvalho, Lethícia De Oliveira ; Silva, Luiz Henrique Da ; Barbosa Junior, Marcos Antonio Da Silva ; Sousa, Pedro Vinicius Leite De ; Costa, Laurisson Albuquerque Da ; ABSTRACT Background: Visceral leishmaniasis (VL) is an endemic and neglected disease in several countries. In addition to affecting the visceral tissues, kidney alterations are recurrent and result from the pathophysiological implications of infection or drug action during treatment. This review mapped and described renal changes, renal biomarkers, and treatment-related nephrotoxicity in humans with confirmed VL. Methods: This scoping review was conducted in accordance with the Joanna Briggs Institute Manual for Evidence Synthesis and the PRISMA-ScR guidelines. PubMed, SciELO, ScienceDirect, Scopus, and Web of Science. were searched with no temporal or geographical restrictions. We included studies involving humans with confirmed VL that reported renal alterations, kidney injury biomarkers, or treatment-related nephrotoxicity. Two reviewers independently screened the records and extracted data. Study selection was documented using the PRISMA-ScR flowchart. Results: In total, 1,444 studies were identified, of which 15 met the eligibility criteria. The included studies reported a wide spectrum of renal alterations in VL, including urinary abnormalities, kidney injury biomarkers, and acute kidney injury. Glomerular and tubulointerstitial changes, such as mesangial alterations, membranoproliferative patterns, cryoglobulinemia, interstitial nephritis, and impaired urinary concentrating ability, have also been described. Reports have also addressed the potential treatment-related nephrotoxicity. Conclusion: This scoping review identified diverse renal alterations in patients with VL, ranging from functional changes and urinary abnormalities to glomerular and tubulointerstitial involvement. Evidence has also described biomarkers of kidney injury and potential treatment-related nephrotoxicity. The heterogeneity and limited data highlight the need for robust research to clarify the underlying mechanisms, diagnostic markers, and optimal management.
2020-08-09
Alay, Handan, Gözgeç, Elif
Alay, Handan ; Gözgeç, Elif ;
2020-08-09
Santos, Lucas Benício dos, Elizeu, Rafael Henrique Bento, Figueredo, Lida Jouca de Assis, Leal, Élida Aparecida, Miranda, Silvana Spíndola de
Santos, Lucas Benício Dos ; Elizeu, Rafael Henrique Bento ; Figueredo, Lida Jouca De Assis ; Leal, Élida Aparecida ; Miranda, Silvana Spíndola De ;
2020-08-09
Alay, Ragıp Afşın, Gözgeç, Elif, Aksakal, Alperen, Alay, Handan
Alay, Ragıp Afşın ; Gözgeç, Elif ; Aksakal, Alperen ; Alay, Handan ;
2020-08-09
Thomas, Cintia Lepaus, Soares, Karllian Kerlen Simonelli, Cola, João Paulo, Prado, Thiago Nascimento do, Maciel, Ethel Leonor Noia
Thomas, Cintia Lepaus ; Soares, Karllian Kerlen Simonelli ; Cola, João Paulo ; Prado, Thiago Nascimento Do ; Maciel, Ethel Leonor Noia ;
2020-08-09
Gleiser, Raquel Miranda, Marcondes, Carlos Brisola, Ximenes, Maria de Fátima Freire de Melo
Gleiser, Raquel Miranda ; Marcondes, Carlos Brisola ; Ximenes, Maria De Fátima Freire De Melo ;
2020-08-09
Ribeiro, Bianca Coelho Damin, Oliveira, Tatiana Fortes de, Viana, Tiago Rodrigues, Feuser, Giovana Volpato Pazin, Fernandes, Fernanda Ferreira, Hueb, Marcia
Ribeiro, Bianca Coelho Damin ; Oliveira, Tatiana Fortes De ; Viana, Tiago Rodrigues ; Feuser, Giovana Volpato Pazin ; Fernandes, Fernanda Ferreira ; Hueb, Marcia ; ABSTRACT Background: Leishmaniasis is a neglected tropical infectious disease caused by protozoa of the Leishmania genus and transmitted by the bite of female sand flies. It may present with various clinical manifestations depending on species, parasite load, and host immunity. Recently, a geographic expansion of the disease has been observed, along with variations in clinical manifestations. Methods: We aimed to better define this clinical entity in the Brazilian context by describing leishmaniasis cases with atypical clinical manifestations treated at the Júlio Müller University Hospital in Cuiabá, Mato Grosso, between 2013 and 2023. Results: During the study period, 1,041 cases of cutaneous and mucosal leishmaniasis and 51 suspected cases of visceral leishmaniasis were recorded, of which 47 were classified as atypical (4.5%). Atypical presentations included localized cutaneous forms with unusual morphology (91.5%), mucocutaneous forms (4.2%), one case resembling post-kala-azar dermal leishmaniasis (2.1%), and one case of mucocutaneous lesions occurring after visceral leishmaniasis (2.1%), both of which are considered atypical in Brazil, where there is no endemic description of post-kala-azar dermal leishm aniasis. Most cases involved men aged 50-59 years, who were predominantly rural workers. These cases primarily originated from the Cerrado biome. The lesions had a median evolution of 120 d and mainly affected the lower limbs and face. Uncommon symptoms included fever, weight loss, and hepatosplenomegaly. Molecular identification of the etiological agent contributed to the diagnosis of selected cases. Conclusions: This study highlights the importance of recognizing atypical clinical manifestations of leishmaniasis to improve disease diagnosis and management.
2020-08-09
Topaloglu, Omer, Sevilgen, Gokcen, Okcu, Oguzhan, Turut, Hasan
Topaloglu, Omer ; Sevilgen, Gokcen ; Okcu, Oguzhan ; Turut, Hasan ; ABSTRACT Actinomycosis is a chronic, suppurative infection caused by Actinomyces israelii, an anaerobic bacterium that is part of the normal oral flora. A 47-year-old woman presented to the clinic with dyspnea and sore throat. Computed tomography(CT) revealed thickening of the proximal tracheal lumen and airway narrowing. Pathological examination of biopsy specimens obtained by rigid bronchoscopy revealed periodic acid-Schiff (PAS)(+) bacterial colonization with filamentous bacilli, consistent with Actinomyces. This report describes an uncommon presentation of tracheal actinomycosis in which tracheal dilatation was performed for both diagnostic sampling and therapeutic management of tracheal stenosis.