Nature Reviews Gastroenterology & Hepatology

Publisher:: Springer Nature
ISSN:: 1759-5045
Category:: GASTROENTEROLOGY & HEPATOLOGY
Impact factor:: 45.9

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Therapeutic targets for metabolic dysfunction-associated steatohepatitis: a personalized approach to disease management

2026-03-18

Mary E. Rinella, Silvia Sookoian

Nature Reviews Gastroenterology & Hepatology, Published online: 18 March 2026; doi:10.1038/s41575-026-01187-8 Current drug approvals reshape metabolic dysfunction-associated steatohepatitis (MASH) therapeutic strategies. This Review highlights current and emerging therapeutic targets and discusses a mechanism-based framework for personalized, combination-oriented management in MASH.

Defining ‘gut health’: a leap forward, but still some road to travel

2026-03-17

Benjamin H. Mullish

Nature Reviews Gastroenterology & Hepatology, Published online: 17 March 2026; doi:10.1038/s41575-026-01189-6 ‘Gut health’ is a widely used term, but there is much uncertainty and inconsistency related to its use. An international panel has now provided a definition that includes consideration of both gastrointestinal function and symptom burden. While advancing the field, the definition also prompts a number of areas of debate.

ECCO’26

2026-03-06

Katrina Ray

Nature Reviews Gastroenterology & Hepatology, Published online: 06 March 2026; doi:10.1038/s41575-026-01194-9 ECCO’26