2026-10-16
Xiao-Dong Zhou, Frank Tacke, Rohit Loomba, Jeffrey V. Lazarus, Luca Valenti, Laurence S. Sperling, Zobair M. Younossi, Jacob George, Mark Muthiah, Arun Sanyal, Ming-Hua Zheng
As metabolic dysfunction-associated steatotic liver disease changes the clinical profile and care needs of patients with liver disease, hepatology training must extend beyond traditional organ-based boundaries. Hepatologists will increasingly need skills in cardiovascular, kidney and metabolic risk assessment, treatment co-management and referral, alongside their core expertise in liver disease.
DOI: 10.1038/s41575-026-01270-02026-10-13
Hannah Esser, Sofia Ferreira-Gonzalez
Primary cilia, organelles found in cholangiocytes, regulate biliary homeostasis and regeneration. This Review discusses how alterations in primary-cilium structure and function can lead to biliary ciliopathies and provides a detailed overview of the underlying mechanisms.
DOI: 10.1038/s41575-026-01262-02026-10-05
Jordan Hindson
DOI: 10.1038/s41575-026-01269-72026-10-05
Jordan Hindson
DOI: 10.1038/s41575-026-01268-82026-10-05
Jordan Hindson
DOI: 10.1038/s41575-026-01267-92026-09-29
Tanyaporn Chantarojanasiri, Lung Yi Mak, Louis H. S. Lau, Marc Wong, Nikhil Sonthalia, Sonam Mathur, Enrik John T. Aguila, Ren Mao, Koji Otani, Rashid Lui, Raja Affendi Raja Ali, Daniel Q. Huang
Asia bears a disproportionate burden of digestive and liver diseases but remains under-represented in global research leadership. This Comment examines structural, cultural and institutional barriers to developing clinician-scientists in Asia, highlights successful regional models and proposes strategies to strengthen training, mentorship and research capacity.
DOI: 10.1038/s41575-026-01261-12026-09-23
Katrina Ray
DOI: 10.1038/s41575-026-01263-z2026-09-18
Manasi Agrawal, Vishal Midya, Alvise Vianello, Damaskini Valvi, Gilaad G. Kaplan, Jean-Frederic Colombel
The environment is a critical factor in the development of inflammatory bowel disease (IBD). In this Perspective, the authors summarize the latest evidence on the exposome and IBD risk, encompassing physical, chemical, biological and psychosocial components. They discuss innovation and challenges alongside a framework for IBD prevention by modulating the exposome.
DOI: 10.1038/s41575-026-01260-22026-03-18
Mary E. Rinella, Silvia Sookoian
Nature Reviews Gastroenterology & Hepatology, Published online: 18 March 2026; doi:10.1038/s41575-026-01187-8 Current drug approvals reshape metabolic dysfunction-associated steatohepatitis (MASH) therapeutic strategies. This Review highlights current and emerging therapeutic targets and discusses a mechanism-based framework for personalized, combination-oriented management in MASH.
2026-03-17
Benjamin H. Mullish
Nature Reviews Gastroenterology & Hepatology, Published online: 17 March 2026; doi:10.1038/s41575-026-01189-6 ‘Gut health’ is a widely used term, but there is much uncertainty and inconsistency related to its use. An international panel has now provided a definition that includes consideration of both gastrointestinal function and symptom burden. While advancing the field, the definition also prompts a number of areas of debate.
2026-03-06
Katrina Ray
Nature Reviews Gastroenterology & Hepatology, Published online: 06 March 2026; doi:10.1038/s41575-026-01194-9 ECCO’26