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2026-03-24
Jianjian Huang, Fangrui Zhong
Nature Synthesis, Published online: 24 March 2026; doi:10.1038/s44160-026-01043-2 Redesigning non-haem iron enzymes to incorporate a nickel centre enables ligand-to-metal charge transfer-driven photoenzymatic C(sp²)–S cross-coupling.
2026-03-24
Longhui Chen, Chenming Zu, Fengyuan Zhang, Yahui Ding, Yu-Xin Luan, Li Chen, Pingping Tang
Nature Synthesis, Published online: 24 March 2026; doi:10.1038/s44160-026-01035-2 An oxidative activation strategy using pyridyl phosphonium salts and potassium persulfate is reported. This approach, which governs the reaction pathway, enables the synthesis of C4-fluorinated and C4-trifluoromethylaminated pyridines with a broad functional group tolerance and is used for the late-stage synthesis and modification of bioactive molecules.
2026-03-23
Pavel Ivashkin, Jonathan Decaens, Isabelle Marchand, Matthieu Hedouin, Hassan Oulyadi, Thomas Poisson, Philippe Jubault
Nature Synthesis, Published online: 23 March 2026; doi:10.1038/s44160-026-01001-y Fluoroform (HFC-23) is a potent greenhouse gas by-product produced in multi-tonne quantities. Here the valorization of HFC-23 into a fluorinated C2 reagent, trifluorovinylamine, which can be used in transformations to prepare fluorinated molecules, is reported.
2026-03-23
Chaoran Xu, Yu Kong, Asja A. Kroeger, Michelle L. Coote, Xiangcheng Pan
Nature Synthesis, Published online: 23 March 2026; doi:10.1038/s44160-026-01005-8 Radical polymerization has successfully incorporated C2 (vinyl) and C4 (diene) backbones, but achieving efficient C3 polymerization remains a major challenge. Now, a strategy for C3 alternating copolymerization that uses 1,2-boryl migration and radical polarity matching is reported to enable precise control over copolymer architectures.