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8 parsed articles
Last update: 2026-09-21
2026-09-18
Michelle L. Swift, Cody M. Rogers, Hardeep Kaur, Dipanjan Chowdhury, Patrick Sung
This Review focuses on the choice between homologous recombination and non-homologous end joining in DNA double-strand break repair. The antagonistic roles of 53BP1 and BRCA1–BARD1, the contribution of RNA–DNA hybrids and implications for targeting repair imbalance in cancer are discussed.
DOI: 10.1038/s41580-026-01026-32026-09-14
Arnaud R. Krebs, Nicolas Altemose, L. Stirling Churchman, William J. Greenleaf, Vijay Ramani, Michael B. Stadler, Andrew B. Stergachis
Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling quantification of molecular heterogeneity and co-occurrence of regulatory events. This Expert Recommendation article provides a practical guide for adopting single-molecule genomics and outlines best practices.
DOI: 10.1038/s41580-026-01017-42026-09-11
Chen Davidovich
Four recent studies that have differently assessed PRC2–RNA interactions reveal key technical pitfalls underlying research in the field.
DOI: 10.1038/s41580-026-01028-12026-09-09
Anne Wentink, Rina Rosenzweig, Harm Kampinga, Bernd Bukau
DOI: 10.1038/s41580-026-01029-02026-09-04
Xizi Chen, Yanhui Xu
Recent technological breakthroughs have transformed our understanding of how transcription initiation in eukaryotes is regulated. This Review discusses the dynamics and roles of initiation-relevant protein complexes, and how chromatin states regulate the selection of transcription start sites and transcription directionality.
DOI: 10.1038/s41580-026-01019-22026-09-04
Akos Diosdi, Fabian J. Theis, Peter Horvath
Combined analyses of cellular omics, morphology and spatial context in 3D-oids would advance tissue studies and organ engineering.
DOI: 10.1038/s41580-026-01025-42026-09-03
Lisa Heinke
During mitosis, the m6A methyltransferase METTL3 regulates transcription through functional interplay with the positive transcription elongation factor P-TEFb.
DOI: 10.1038/s41580-026-01027-22026-08-28
Florencia Pratto
A 2010 paper identified PRDM9 as the sequence-specific regulator of meiotic recombination hotspots, showing it co-evolves with its rapidly changing binding motifs.
DOI: 10.1038/s41580-026-01020-9