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28 parsed articles
Last update: 2026-09-22
2026-09-18
Michelle L. Swift, Cody M. Rogers, Hardeep Kaur, Dipanjan Chowdhury, Patrick Sung
This Review focuses on the choice between homologous recombination and non-homologous end joining in DNA double-strand break repair. The antagonistic roles of 53BP1 and BRCA1–BARD1, the contribution of RNA–DNA hybrids and implications for targeting repair imbalance in cancer are discussed.
DOI: 10.1038/s41580-026-01026-32026-09-14
Arnaud R. Krebs, Nicolas Altemose, L. Stirling Churchman, William J. Greenleaf, Vijay Ramani, Michael B. Stadler, Andrew B. Stergachis
Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling quantification of molecular heterogeneity and co-occurrence of regulatory events. This Expert Recommendation article provides a practical guide for adopting single-molecule genomics and outlines best practices.
DOI: 10.1038/s41580-026-01017-42026-09-11
Chen Davidovich
Four recent studies that have differently assessed PRC2–RNA interactions reveal key technical pitfalls underlying research in the field.
DOI: 10.1038/s41580-026-01028-12026-09-09
Anne Wentink, Rina Rosenzweig, Harm Kampinga, Bernd Bukau
DOI: 10.1038/s41580-026-01029-02026-09-04
Xizi Chen, Yanhui Xu
Recent technological breakthroughs have transformed our understanding of how transcription initiation in eukaryotes is regulated. This Review discusses the dynamics and roles of initiation-relevant protein complexes, and how chromatin states regulate the selection of transcription start sites and transcription directionality.
DOI: 10.1038/s41580-026-01019-22026-09-04
Akos Diosdi, Fabian J. Theis, Peter Horvath
Combined analyses of cellular omics, morphology and spatial context in 3D-oids would advance tissue studies and organ engineering.
DOI: 10.1038/s41580-026-01025-42026-09-03
Lisa Heinke
During mitosis, the m6A methyltransferase METTL3 regulates transcription through functional interplay with the positive transcription elongation factor P-TEFb.
DOI: 10.1038/s41580-026-01027-22026-08-28
Florencia Pratto
A 2010 paper identified PRDM9 as the sequence-specific regulator of meiotic recombination hotspots, showing it co-evolves with its rapidly changing binding motifs.
DOI: 10.1038/s41580-026-01020-92026-07-15
Supriya V. Vartak
Nature Reviews Molecular Cell Biology, Published online: 15 July 2026; doi:10.1038/s41580-026-01001-y Already thirty years ago, DNA replication, transcription and repair machineries were proposed to form and function in nuclear ‘factories’, later also dubbed hubs and condensates.]]>
DOI: 10.1038/s41580-026-01001-y2026-07-10
Haorui Zhang
Nature Reviews Molecular Cell Biology, Published online: 10 July 2026; doi:10.1038/s41580-026-01006-7 SPAC-seq combines spatial transcriptomics and CRISPR screening within the tissue context, to identify how gene perturbations influence cell states and tissues.]]>
DOI: 10.1038/s41580-026-01006-72026-07-03
Ina Yoon
Nature Reviews Molecular Cell Biology, Published online: 03 July 2026; doi:10.1038/s41580-026-00980-2 Aminoacyl-tRNA synthetases attach amino acids to matching tRNAs to ensure accurate translation. This Review discusses new insights into their canonical and emerging non-canonical roles, including in metabolic signalling, stress responses, gene regulation and diseases.]]>
DOI: 10.1038/s41580-026-00980-22026-07-01
James E. Vince
Nature Reviews Molecular Cell Biology, Published online: 01 July 2026; doi:10.1038/s41580-026-00995-9 Reply to ‘Single-cell evidence for PANoptosome complexes’]]>
DOI: 10.1038/s41580-026-00995-92026-06-30
Yuxiang Chen
Nature Reviews Molecular Cell Biology, Published online: 30 June 2026; doi:10.1038/s41580-026-00998-6 In this Tools of the Trade, Chen & Cheng (Barna lab) describe the development of Ribo-Tweezer, a method that enables the targeted degradation of individual ribosomal proteins of the cytoplasmic ribosome.]]>
DOI: 10.1038/s41580-026-00998-62026-06-19
Shiyu Liu
Nature Reviews Molecular Cell Biology, Published online: 19 June 2026; doi:10.1038/s41580-026-00982-0 Tunnelling nanotubes, cytonemes and migrasomes are specialized membrane protrusions that mediate intercellular transfer of signalling molecules, organelles and other cargo. This Review discusses recent advances in their formation, architecture and transport functions, and examines their roles in development and disease.]]>
DOI: 10.1038/s41580-026-00982-02026-06-09
Temurkhan Ayupov
Nature Reviews Molecular Cell Biology, Published online: 09 June 2026; doi:10.1038/s41580-026-00986-w In this Tools of the Trade article, Ayupov (Roska lab) describes the development of MitoCatch, a method to display protein binders on the mitochondrial surface to facilitate cell-type-specific targeting during mitochondrial transplantation.]]>
DOI: 10.1038/s41580-026-00986-w2026-06-08
Eytan Zlotorynski
Nature Reviews Molecular Cell Biology, Published online: 08 June 2026; doi:10.1038/s41580-026-00987-9 This study shows that genomic DNA in the cytoplasm can transfer between mammalian cells through nanotube-like structures, integrate into the genome of recipient cells and support gene expression.]]>
DOI: 10.1038/s41580-026-00987-92026-05-20
Janna Puschmann
Nature Reviews Molecular Cell Biology, Published online: 20 May 2026; doi:10.1038/s41580-026-00981-1 Several mechanisms have been described for the release and transport of Hedgehog morphogens. Here, Grobe and Puschmann propose a unified model in which these pathways interact synergistically.]]>
DOI: 10.1038/s41580-026-00981-12026-05-12
Wee Siong Sho Goh
Nature Reviews Molecular Cell Biology, Published online: 12 May 2026; doi:10.1038/s41580-026-00976-y Direct RNA sequencing by the Oxford nanopore technology enabled simultaneous mapping of different RNA modifications on the same RNA molecule and opened new avenues for studying the physiological roles of RNA modifications.]]>
DOI: 10.1038/s41580-026-00976-y2026-04-21
James E. Vince
Nature Reviews Molecular Cell Biology, Published online: 21 April 2026; doi:10.1038/s41580-026-00970-4 The concept of PANoptosis describes the simultaneous activation of pyroptosis, apoptosis and necroptosis. This Comment discusses the evidence supporting this hypothesis and proposes criteria to validate PANoptosis.]]>
DOI: 10.1038/s41580-026-00970-42026-04-21
Robin E. Stanley
Nature Reviews Molecular Cell Biology, Published online: 21 April 2026; doi:10.1038/s41580-026-00963-3 This Review discusses the expression and maturation of human cytoplasmic tRNAs and recent insights into their regulation of translation. The authors also explore emerging roles of tRNAs in ribosome-associated quality control and in the integrated stress response and how tRNA dysregulation contributes to human pathologies.]]>
DOI: 10.1038/s41580-026-00963-32026-04-20
Nadine Martin
Nature Reviews Molecular Cell Biology, Published online: 20 April 2026; doi:10.1038/s41580-026-00973-1 David Bernard and colleagues discuss the complexity of roles of cell senescence and argue that it is crucial to study their contributions to both normal develoment and physiology, and to disease states in order to understand and manipulate cell senescence for therapeutic purposes.]]>
DOI: 10.1038/s41580-026-00973-12026-04-10
Maksim V. Plikus
Nature Reviews Molecular Cell Biology, Published online: 10 April 2026; doi:10.1038/s41580-026-00972-2 Maksim Plikus discusses Alan Turing’s 1952 reaction–diffusion theory, which describes how diverse skin patterns occur, and later molecular data, from developmental mechanisms to disease, supporting the theory.]]>
DOI: 10.1038/s41580-026-00972-22026-04-10
Wei Wang
Nature Reviews Molecular Cell Biology, Published online: 10 April 2026; doi:10.1038/s41580-026-00966-0 In this Tools of the Trade article, Song and Wang describe a strategy of targeted protein degradation that harnesses endoplasmic reticulum (ER)-associated degradation machinery to degrade transmembrane proteins.]]>
DOI: 10.1038/s41580-026-00966-02026-04-03
Eytan Zlotorynski
Nature Reviews Molecular Cell Biology, Published online: 03 April 2026; doi:10.1038/s41580-026-00965-1 Nuclear speckles support the splicing of levelled exon–intron architecture transcripts, and their evolution shaped genome organization in amniotes.]]>
DOI: 10.1038/s41580-026-00965-12026-04-02
Yuefeng Ma
Nature Reviews Molecular Cell Biology, Published online: 02 April 2026; doi:10.1038/s41580-026-00968-y In this Tools of the Trade article, Ma (Dai lab) discusses the design of synthetic intrinsically disordered proteins that can be used to regulate the solubility of intracellular proteins, thereby affecting their activity.]]>
DOI: 10.1038/s41580-026-00968-y2026-03-30
Soumyabrata Guha, Nadine Laguette
Nature Reviews Molecular Cell Biology, Published online: 30 March 2026; doi:10.1038/s41580-026-00967-z This Comment discusses the bidirectional interplay between STING signalling and lipid homeostasis, highlighting the emerging therapeutic relevance of this regulatory network.
2026-03-26
Yang Yang, Bin Liu
Nature Reviews Molecular Cell Biology, Published online: 26 March 2026; doi:10.1038/s41580-026-00962-4 Yang and Liu discuss strategies that help address particle orientation bias in cryogenic electron microscopy (cryo-EM), and offer practical advice to tackle it.
2026-02-27
Rongrong Du
Nature Reviews Molecular Cell Biology, Published online: 27 February 2026; doi:10.1038/s41580-026-00959-z Based on microRNAs, DIMMERs is a modular tool for dampening expression fluctuations of multiple proteins in a cell owing to transgene copy number variations.