2026-10-21
Qing Liu, Ying Cheng, Dandan Yan, Wenjie Wu, Zhenchuan Lei, Qiaoyun Long, Ziyu Zhao, Yuan Gao, Baile Wang, Tianshi Feng, Jihoon Shin, Jiayu Zhao, Shiting Zhao, Kang Chen, Kingyip Cheng, Xiaoqiang Yao, Ping Gu, Xuefei Gao, Ching-Lung Cheung, Shingo Kajimura, Pengtao Liu, Donghai Wu, Wei Sun, Jinfeng Xiao, Zexin Lin, Yi Wang, Maxwell Kwok, Ngar Yun Ellen Poon, Cheng Hu, Aimin Xu, Hannah Xiaoyan Hui
A futile Na+ K+ transport cycle, which is preferentially active in beige adipocytes, is shown to promote energy expenditure independent of uncoupling protein 1.
DOI: 10.1038/s42255-026-01630-92026-10-16
Weiwei Huang, Chuanjin Yu, Yishu Wang, Ningxia Sun, Liang Wang, Jun Ren, Yue Xu, Xinghui Guo, Xinyuan Li, Yiting Mao, Jiexue Pan, Tingting Liu, Hongbo Yang, Hefeng Huang
Nicotinamide N-methyltransferase promotes and sustains hyperandrogenism in polyendocrine metabolic ovarian syndrome through metabolic and epigenetic reprogramming.
DOI: 10.1038/s42255-026-01625-62026-10-15
Sreekala Nampoothiri, Daniela Fernandois, Nathalie Journiac, Fabien Delahaye, Yvon Mbouamboua, Florent Sauve, Marie Couralet, Sarah Gallet, Naziha Mroueh, Maria Laura Serradas Aponte, Nathalie Jouy, Rachel Spenle, Ruth Schmidt-Ullrich, Ines Martinez Corral, Virginie Mattot, Carmen Ruiz de Almodovar, Andreas Schlitzer, Philippe Froguel, Claude-Alain Maurage, Pascal Barbry, Paolo Giacobini, Lennart T. Mars, Amelie Bonnefond, Ruben Nogueiras, Markus Schwaninger, Vincent Prevot
This study reports a cellular map of the mouse and human mediobasal hypothalamus, revealing an immune cell-like state of tanycytes, which is influenced by sex and the ovarian cycle.
DOI: 10.1038/s42255-026-01635-42026-10-15
Xiao Liu, Lili Yang, Jingjing Jiang, Hsun-Ming Chang, Liangshan Mu
This Review highlights the interplay between metabolic homeostasis and female reproductive health and examines metabolism-focused therapeutic strategies for disorders that intersect the reproductive and metabolic systems, such as polyendocrine metabolic ovarian syndrome.
DOI: 10.1038/s42255-026-01646-12026-10-14
Xingxiu Pan, Austin L. Zuckerman, Karl N. Miller, Marcos G. Teneche, Subrata Munan, Andrew Pon, Niklas B. Thompson, Rasangi M. Perera, Roya AminiTabrizi, Adarsh Rajesh, Sara Violante, Jiwu Wang, Justin R. Cross, Peter D. Adams, Hardik Shah, Valentin Cracan
Using genetically encoded tools that shift the redox equilibrium, the authors identify a link between oxidative and reductive stress, suggesting that simultaneously targeting NAD(P)H homeostasis could be a therapeutic strategy for age-related redox-driven metabolic vulnerabilities.
DOI: 10.1038/s42255-026-01640-72026-10-12
A single bout of exercise triggers thousands of coordinated protein changes across blood, saliva and urine. By integrating tissue atlases, human genetics and in vivo functional validation, we present a multi-fluid resource that serves as a starting point for prioritizing robust candidate exercise-regulated proteins that might mediate the cardiometabolic health benefits of long-term exercise.
DOI: 10.1038/s42255-026-01642-52026-10-12
Nigel Kurgan, Jeppe Kjærgaard, Naja Zenius Jespersen, Virginia Díez-Obrero, Victor Svenstrup, Roger Moreno-Justicia, Sarah Elizabeth Heywood, Cecilie Bergmann Lindqvist, Lisa Ottander, Diana Samodova-Sommer, Alina Malita, Olga Kubrak, Nadja Ahrentløv, Nina Sloth Nielsen, Cody Garett Durrer, Michael Texada, Mathias Ried-Larsen, Simon Rasmussen, Kim Rewitz, Ruth J. F. Loos, Roelof Adriaan Johan Smit, Bente Klarlund Pedersen, Atul Shahaji Deshmukh
This study provides a comprehensive, systems-level characterization of acute exercise-induced proteomic responses across several body fluids in humans.
DOI: 10.1038/s42255-026-01621-w2026-10-07
Richard J. Johnson, Miguel A. Lanaspa, Dean R. Tolan
In this issue of Nature Metabolism, Koene et al. present evidence that inhibiting fructose metabolism (using a ketohexokinase inhibitor) can improve hepatic steatosis and insulin resistance in individuals who are prediabetic with obesity and metabolic dysfunction-associated steatotic liver disease, supporting further development and testing of fructose inhibitors in metabolic disease.
DOI: 10.1038/s42255-026-01627-42026-04-01
Michael C. Noji, Kathryn E. Wellen
Nature Metabolism, Published online: 01 April 2026; doi:10.1038/s42255-026-01500-4 Two studies published in Nature Metabolism show that dysregulation of specific metabolic enzymes within the pancreas leads to increased oxidative stress, which promotes pancreatic neoplasia in the presence of oncogenic KRAS mutations.
2026-04-01
Megan D. Radyk, Barbara S. Nelson, Mariana Tannus Ruckert, Christopher J. Halbrook, Mengrou Shan, Jonathan M. Alektiar, Brooke L. Lavoie, Lucie Salvatore, Wei Yan, Matthew D. Perricone, Kathryn Buscher, Alexander Wood, Hanna S. Hong, Peter Sajjakulnukit, Li Zhang, Gabriel Corfas, Filip Bednar, Timothy L. Frankel, Marina Pasca di Magliano, Justin A. Colacino, Yatrik M. Shah, Howard C. Crawford, Costas A. Lyssiotis
Nature Metabolism, Published online: 01 April 2026; doi:10.1038/s42255-026-01496-x Temporal profiling of central carbon metabolism during KrasG12D-driven acinar-to-ductal metaplasia reveals that disruptions in NADPH-producing enzymes accelerate the formation of pancreatic precancerous lesions.
2026-03-26
Jonathan Williams, Woo Sung Kim, Rebecca Danner, Juyeong Cho, Bianca F. Silva, David A. Harris, Federico E. Rey, Snehal N. Chaudhari
Nature Metabolism, Published online: 26 March 2026; doi:10.1038/s42255-026-01489-w The authors provide an interactive resource of folate one-carbon metabolism in 37 tissues in germ-free and conventional mice.
2026-03-24
Amélie Bonnefond, Winter S. Bruner, Struan F. A. Grant, Anita Morandi, Philippe Froguel
Nature Metabolism, Published online: 24 March 2026; doi:10.1038/s42255-026-01497-w This Review discusses the genetics of obesity, highlighting its diverse forms and describing technological advancements in genetic studies that may enable precision medicine strategies to combat obesity.
2026-03-23
Jessica Segalés, Marc Liesa
Nature Metabolism, Published online: 23 March 2026; doi:10.1038/s42255-026-01483-2 By determining the organellar topology and proteome of fat-oxidizing and fat-synthesizing hepatocytes, Kang et al. show that perilipin 5-mediated mitochondria–lipid droplet contacts facilitate the expansion of lipid droplets in both populations and are impaired in early metabolic dysfunction-associated steatotic liver disease (MASLD).