Feed status
5 parsed articles
Last update: Not fetched
2026-04-01
Michael C. Noji, Kathryn E. Wellen
Nature Metabolism, Published online: 01 April 2026; doi:10.1038/s42255-026-01500-4 Two studies published in Nature Metabolism show that dysregulation of specific metabolic enzymes within the pancreas leads to increased oxidative stress, which promotes pancreatic neoplasia in the presence of oncogenic KRAS mutations.
2026-04-01
Megan D. Radyk, Barbara S. Nelson, Mariana Tannus Ruckert, Christopher J. Halbrook, Mengrou Shan, Jonathan M. Alektiar, Brooke L. Lavoie, Lucie Salvatore, Wei Yan, Matthew D. Perricone, Kathryn Buscher, Alexander Wood, Hanna S. Hong, Peter Sajjakulnukit, Li Zhang, Gabriel Corfas, Filip Bednar, Timothy L. Frankel, Marina Pasca di Magliano, Justin A. Colacino, Yatrik M. Shah, Howard C. Crawford, Costas A. Lyssiotis
Nature Metabolism, Published online: 01 April 2026; doi:10.1038/s42255-026-01496-x Temporal profiling of central carbon metabolism during KrasG12D-driven acinar-to-ductal metaplasia reveals that disruptions in NADPH-producing enzymes accelerate the formation of pancreatic precancerous lesions.
2026-03-26
Jonathan Williams, Woo Sung Kim, Rebecca Danner, Juyeong Cho, Bianca F. Silva, David A. Harris, Federico E. Rey, Snehal N. Chaudhari
Nature Metabolism, Published online: 26 March 2026; doi:10.1038/s42255-026-01489-w The authors provide an interactive resource of folate one-carbon metabolism in 37 tissues in germ-free and conventional mice.
2026-03-24
Amélie Bonnefond, Winter S. Bruner, Struan F. A. Grant, Anita Morandi, Philippe Froguel
Nature Metabolism, Published online: 24 March 2026; doi:10.1038/s42255-026-01497-w This Review discusses the genetics of obesity, highlighting its diverse forms and describing technological advancements in genetic studies that may enable precision medicine strategies to combat obesity.
2026-03-23
Jessica Segalés, Marc Liesa
Nature Metabolism, Published online: 23 March 2026; doi:10.1038/s42255-026-01483-2 By determining the organellar topology and proteome of fat-oxidizing and fat-synthesizing hepatocytes, Kang et al. show that perilipin 5-mediated mitochondria–lipid droplet contacts facilitate the expansion of lipid droplets in both populations and are impaired in early metabolic dysfunction-associated steatotic liver disease (MASLD).