Signal Transduction and Targeted Therapy

Publisher:: Springer Nature
ISSN:: 2095-9907
Category:: CELL BIOLOGY
Impact factor:: 40.8

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45 parsed articles

Last update: 2026-10-23

Latest articles

Arrhythmic events and genetic variants as drivers for Takotsubo Syndrome: a patient-specific atrial stem-cell model

2026-10-23

Charlotte Brand, Clarissa Zinke, Gideon Syed Ali, Daniela Hübscher, Karim Ajmail, Aylin Seedorf, Pauline Steinker, Franziska Treu, Philipp Jung, Hanna Eberl, Yun Li, Nataliya Dybkova, Lukas Feld, Jelena R. Ghadri, Christian Templin, Samuel Sossalla, Christoph Maack, Niels Voigt, Viacheslav O. Nikolaev, Bernd Wollnik, Katrin Streckfuss-Bömeke

DOI: 10.1038/s41392-026-03000-z

Nicotinic acid starvation sensitizes nicotinate phosphoribosyltransferase-expressing tumors to nicotinamide phosphoribosyltransferase inhibition

2026-10-22

Moustafa S. Ghanem, Silvia Ravera, Roberto Benelli, Aimable Nahimana, Francesco Piacente, Irene Caffa, Alessio Nencioni

DOI: 10.1038/s41392-026-03007-6

An iron compass in the liver: superparamagnetic macrophages give homing pigeons a magnetic sense

2026-10-21

Yun Liu, Jincheng Fang, Roman Sankowski

DOI: 10.1038/s41392-026-03004-9

From cryptic exons to neuronal dysfunction: combinatorial antisense makes sense in TAR DNA-binding protein-43 (TDP-43) pathology

2026-10-21

Gianluca Figlia, Juliane Bremer

DOI: 10.1038/s41392-026-03002-x

Nanotherapeutic macrophage reprogramming through immunometabolic and microbial modulation for sepsis treatment

2026-10-21

Xintong Lu, Wenhui Wang, Bingjie Zhang, Qian Li, Ye Chen, Yongrui Hai, Renming Fan, Shuo Fu, Jiaxin Yan, Guiquan Ding, Zhuang Hou, Junke Song, Maosheng Cheng, Gaofei Wei

DOI: 10.1038/s41392-026-02947-3

Entinostat plus exemestane for hormone receptor-positive advanced breast cancer: long-term overall survival results from the EOC103A3101 randomized controlled trial

2026-10-20

Jiani Wang, Qingyuan Zhang, Xichun Hu, Tao Sun, Wei Li, Quchang Ouyang, Jingfen Wang, Zhongsheng Tong, Min Yan, Huiping Li, Xiaohua Zeng, Changping Shan, Xian Wang, Jian Zhang, Yue Zhang, Liang Zhang, Hongyan Shang, Binghe Xu

DOI: 10.1038/s41392-026-02899-8

Mitophagy coordinates organelle crosstalk in health and diseases

2026-10-20

Mengyao Wu, Pengyi He, Yajun Lian, Tuo Zhang, Yiqi Wu, Lu Wang, Daolin Tang, Yongming Yao, Renqi Yao

DOI: 10.1038/s41392-026-02812-3

Cytokine context shapes antigen-presenting and matrix-producing states of cancer-associated fibroblasts

2026-10-20

Feifei Song, Qi Chen, Dengfeng Huang, Youhua Zhang, Dongyan Han, Wei Rao, Man Li, Yaohui Gao, Renfeng Zhang, Huiyuan Zhu, Shufei Wang, Xiao Jiang, Shengli Lin, Dexi Bi, Haixian Zhang, Qing Wei, Huanlong Qin

DOI: 10.1038/s41392-026-02965-1

Mucosal immunity and vaccine development

2026-07-27

Weiqi Hong

Signal Transduction and Targeted Therapy, Published online: 27 July 2026; doi:10.1038/s41392-026-02687-4 Mucosal immunity and vaccine development]]>

DOI: 10.1038/s41392-026-02687-4

Bacteria-mimicking cancer cells reprogram macrophages via multiple pattern recognition receptor pathways for cancer immunotherapy

2026-07-27

Seoyoon Song

Signal Transduction and Targeted Therapy, Published online: 27 July 2026; doi:10.1038/s41392-026-02856-5 Bacteria-mimicking cancer cells reprogram macrophages via multiple pattern recognition receptor pathways for cancer immunotherapy]]>

DOI: 10.1038/s41392-026-02856-5

Mechanisms and therapeutic targets in distant metastasis of lung adenocarcinoma

2026-07-24

Tongji Xie

Signal Transduction and Targeted Therapy, Published online: 24 July 2026; doi:10.1038/s41392-026-02817-y Mechanisms and therapeutic targets in distant metastasis of lung adenocarcinoma]]>

DOI: 10.1038/s41392-026-02817-y

Combinatorial in situ cancer vaccines: unlocking broad and enhanced antitumor responses

2026-07-23

Weihsuan Chen

Signal Transduction and Targeted Therapy, Published online: 23 July 2026; doi:10.1038/s41392-026-02821-2 Combinatorial in situ cancer vaccines: unlocking broad and enhanced antitumor responses]]>

DOI: 10.1038/s41392-026-02821-2

Sound effects: paradigm gene therapy approach installs hearing in children and adolescents born deaf

2026-07-23

Juliane W. Schott

Signal Transduction and Targeted Therapy, Published online: 23 July 2026; doi:10.1038/s41392-026-02879-y Sound effects: paradigm gene therapy approach installs hearing in children and adolescents born deaf]]>

DOI: 10.1038/s41392-026-02879-y

Decoding the regulatory genome: single-cell four-omics integration

2026-07-22

Hakjin Kim

Signal Transduction and Targeted Therapy, Published online: 22 July 2026; doi:10.1038/s41392-026-02874-3 Decoding the regulatory genome: single-cell four-omics integration]]>

DOI: 10.1038/s41392-026-02874-3

Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets

2026-07-20

Kun-Yu Zhang

Signal Transduction and Targeted Therapy, Published online: 20 July 2026; doi:10.1038/s41392-026-02850-x Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets]]>

DOI: 10.1038/s41392-026-02850-x

Ageing stress signalling: metastatic plasticity and metabolic vulnerability in lung cancer

2026-07-16

Seung-Jae Lee

Signal Transduction and Targeted Therapy, Published online: 16 July 2026; doi:10.1038/s41392-026-02828-9 Ageing stress signalling: metastatic plasticity and metabolic vulnerability in lung cancer]]>

DOI: 10.1038/s41392-026-02828-9

Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer’s disease

2026-07-15

Seung Jae Hyeon

Signal Transduction and Targeted Therapy, Published online: 15 July 2026; doi:10.1038/s41392-026-02789-z Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer’s disease]]>

DOI: 10.1038/s41392-026-02789-z

Novel nuclear RNA export factor 1 adaptor drives tumor growth by increasing proliferation-stimulatory mRNA export

2026-07-15

Jin-Yu Liu

Signal Transduction and Targeted Therapy, Published online: 15 July 2026; doi:10.1038/s41392-026-02823-0 Novel nuclear RNA export factor 1 adaptor drives tumor growth by increasing proliferation-stimulatory mRNA export]]>

DOI: 10.1038/s41392-026-02823-0

Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures

2026-07-15

Jinsen Lu

Signal Transduction and Targeted Therapy, Published online: 15 July 2026; doi:10.1038/s41392-026-02799-x Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures]]>

DOI: 10.1038/s41392-026-02799-x

Multiple organ dysfunction syndrome: molecular mechanisms and therapeutic strategies

2026-07-14

Xuan Xu

Signal Transduction and Targeted Therapy, Published online: 14 July 2026; doi:10.1038/s41392-026-02782-6 Multiple organ dysfunction syndrome: molecular mechanisms and therapeutic strategies]]>

DOI: 10.1038/s41392-026-02782-6

Tumor heterogeneity: development, mechanisms, and therapeutic implications

2026-07-13

Jianhong Zhang

Signal Transduction and Targeted Therapy, Published online: 13 July 2026; doi:10.1038/s41392-026-02749-7 Tumor heterogeneity: development, mechanisms, and therapeutic implications]]>

DOI: 10.1038/s41392-026-02749-7

A lipid-tuned bile acid exporter: structural insight into intestinal bile acid efflux

2026-07-09

Hak Min Kim

Signal Transduction and Targeted Therapy, Published online: 09 July 2026; doi:10.1038/s41392-026-02857-4 A lipid-tuned bile acid exporter: structural insight into intestinal bile acid efflux]]>

DOI: 10.1038/s41392-026-02857-4

Switching tumor-derived extracellular vesicles off and on via targeted proteolysis to shift toward immunogenic phenotypes

2026-07-09

Yeongji Jang

Signal Transduction and Targeted Therapy, Published online: 09 July 2026; doi:10.1038/s41392-026-02872-5 Switching tumor-derived extracellular vesicles off and on via targeted proteolysis to shift toward immunogenic phenotypes]]>

DOI: 10.1038/s41392-026-02872-5

Protein lactylation in health and diseases: molecular mechanisms, biological significance, and clinical implications

2026-07-06

Yue Yang

Signal Transduction and Targeted Therapy, Published online: 06 July 2026; doi:10.1038/s41392-026-02757-7 Protein lactylation in health and diseases: molecular mechanisms, biological significance, and clinical implications]]>

DOI: 10.1038/s41392-026-02757-7

Partial downregulation of platelet glycoprotein VI by low affinity antibodies confers sustained and safe antithrombotic protection

2026-07-01

Stefano Navarro

Signal Transduction and Targeted Therapy, Published online: 01 July 2026; doi:10.1038/s41392-026-02864-5 Partial downregulation of platelet glycoprotein VI by low affinity antibodies confers sustained and safe antithrombotic protection]]>

DOI: 10.1038/s41392-026-02864-5

Biologics for cardiovascular diseases: from bench to bedside

2026-06-29

Xiaochi Sun

Signal Transduction and Targeted Therapy, Published online: 29 June 2026; doi:10.1038/s41392-026-02673-w Biologics for cardiovascular diseases: from bench to bedside]]>

DOI: 10.1038/s41392-026-02673-w

Molecular mechanism of allosteric modulation of opioid receptors

2026-06-26

Heli Wang

Signal Transduction and Targeted Therapy, Published online: 26 June 2026; doi:10.1038/s41392-026-02759-5 Molecular mechanism of allosteric modulation of opioid receptors]]>

DOI: 10.1038/s41392-026-02759-5

Potent anti-tumor activity of CD98hc-targeted antibody-drug conjugates in ovarian cancer

2026-06-26

Juan Carlos Montero

Signal Transduction and Targeted Therapy, Published online: 26 June 2026; doi:10.1038/s41392-026-02747-9 Potent anti-tumor activity of CD98hc-targeted antibody-drug conjugates in ovarian cancer]]>

DOI: 10.1038/s41392-026-02747-9

Large-scale and high-resolution mass spectrometry-based proteomics defines molecular subtypes of nasopharyngeal carcinoma for therapeutic targeting

2026-06-23

Yi-Ping Wu

Signal Transduction and Targeted Therapy, Published online: 23 June 2026; doi:10.1038/s41392-026-02742-0 Large-scale and high-resolution mass spectrometry-based proteomics defines molecular subtypes of nasopharyngeal carcinoma for therapeutic targeting]]>

DOI: 10.1038/s41392-026-02742-0

Activity-dependent antioxidant gene therapy protects against epileptogenesis

2026-06-19

Prince Kumar Singh

Signal Transduction and Targeted Therapy, Published online: 19 June 2026; doi:10.1038/s41392-026-02738-w Activity-dependent antioxidant gene therapy protects against epileptogenesis]]>

DOI: 10.1038/s41392-026-02738-w