Mucosal immunity and vaccine development
2026-07-27
Weiqi Hong
Signal Transduction and Targeted Therapy, Published online: 27 July 2026; doi:10.1038/s41392-026-02687-4 Mucosal immunity and vaccine development]]>
DOI: 10.1038/s41392-026-02687-4← Back to Journals
Signal Transduction and Targeted Therapy
- Publisher:
- Springer Nature
- ISSN:
- 2095-9907
- Category:
- CELL BIOLOGY
- Impact factor:
- 40.8
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37 parsed articles
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Latest articles
Bacteria-mimicking cancer cells reprogram macrophages via multiple pattern recognition receptor pathways for cancer immunotherapy
2026-07-27
Seoyoon Song
Signal Transduction and Targeted Therapy, Published online: 27 July 2026; doi:10.1038/s41392-026-02856-5 Bacteria-mimicking cancer cells reprogram macrophages via multiple pattern recognition receptor pathways for cancer immunotherapy]]>
DOI: 10.1038/s41392-026-02856-5Mechanisms and therapeutic targets in distant metastasis of lung adenocarcinoma
2026-07-24
Tongji Xie
Signal Transduction and Targeted Therapy, Published online: 24 July 2026; doi:10.1038/s41392-026-02817-y Mechanisms and therapeutic targets in distant metastasis of lung adenocarcinoma]]>
DOI: 10.1038/s41392-026-02817-yCombinatorial in situ cancer vaccines: unlocking broad and enhanced antitumor responses
2026-07-23
Weihsuan Chen
Signal Transduction and Targeted Therapy, Published online: 23 July 2026; doi:10.1038/s41392-026-02821-2 Combinatorial in situ cancer vaccines: unlocking broad and enhanced antitumor responses]]>
DOI: 10.1038/s41392-026-02821-2Sound effects: paradigm gene therapy approach installs hearing in children and adolescents born deaf
2026-07-23
Juliane W. Schott
Signal Transduction and Targeted Therapy, Published online: 23 July 2026; doi:10.1038/s41392-026-02879-y Sound effects: paradigm gene therapy approach installs hearing in children and adolescents born deaf]]>
DOI: 10.1038/s41392-026-02879-yDecoding the regulatory genome: single-cell four-omics integration
2026-07-22
Hakjin Kim
Signal Transduction and Targeted Therapy, Published online: 22 July 2026; doi:10.1038/s41392-026-02874-3 Decoding the regulatory genome: single-cell four-omics integration]]>
DOI: 10.1038/s41392-026-02874-3Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets
2026-07-20
Kun-Yu Zhang
Signal Transduction and Targeted Therapy, Published online: 20 July 2026; doi:10.1038/s41392-026-02850-x Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets]]>
DOI: 10.1038/s41392-026-02850-xAgeing stress signalling: metastatic plasticity and metabolic vulnerability in lung cancer
2026-07-16
Seung-Jae Lee
Signal Transduction and Targeted Therapy, Published online: 16 July 2026; doi:10.1038/s41392-026-02828-9 Ageing stress signalling: metastatic plasticity and metabolic vulnerability in lung cancer]]>
DOI: 10.1038/s41392-026-02828-9Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer’s disease
2026-07-15
Seung Jae Hyeon
Signal Transduction and Targeted Therapy, Published online: 15 July 2026; doi:10.1038/s41392-026-02789-z Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer’s disease]]>
DOI: 10.1038/s41392-026-02789-zNovel nuclear RNA export factor 1 adaptor drives tumor growth by increasing proliferation-stimulatory mRNA export
2026-07-15
Jin-Yu Liu
Signal Transduction and Targeted Therapy, Published online: 15 July 2026; doi:10.1038/s41392-026-02823-0 Novel nuclear RNA export factor 1 adaptor drives tumor growth by increasing proliferation-stimulatory mRNA export]]>
DOI: 10.1038/s41392-026-02823-0Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures
2026-07-15
Jinsen Lu
Signal Transduction and Targeted Therapy, Published online: 15 July 2026; doi:10.1038/s41392-026-02799-x Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures]]>
DOI: 10.1038/s41392-026-02799-xMultiple organ dysfunction syndrome: molecular mechanisms and therapeutic strategies
2026-07-14
Xuan Xu
Signal Transduction and Targeted Therapy, Published online: 14 July 2026; doi:10.1038/s41392-026-02782-6 Multiple organ dysfunction syndrome: molecular mechanisms and therapeutic strategies]]>
DOI: 10.1038/s41392-026-02782-6Tumor heterogeneity: development, mechanisms, and therapeutic implications
2026-07-13
Jianhong Zhang
Signal Transduction and Targeted Therapy, Published online: 13 July 2026; doi:10.1038/s41392-026-02749-7 Tumor heterogeneity: development, mechanisms, and therapeutic implications]]>
DOI: 10.1038/s41392-026-02749-7A lipid-tuned bile acid exporter: structural insight into intestinal bile acid efflux
2026-07-09
Hak Min Kim
Signal Transduction and Targeted Therapy, Published online: 09 July 2026; doi:10.1038/s41392-026-02857-4 A lipid-tuned bile acid exporter: structural insight into intestinal bile acid efflux]]>
DOI: 10.1038/s41392-026-02857-4Switching tumor-derived extracellular vesicles off and on via targeted proteolysis to shift toward immunogenic phenotypes
2026-07-09
Yeongji Jang
Signal Transduction and Targeted Therapy, Published online: 09 July 2026; doi:10.1038/s41392-026-02872-5 Switching tumor-derived extracellular vesicles off and on via targeted proteolysis to shift toward immunogenic phenotypes]]>
DOI: 10.1038/s41392-026-02872-5Protein lactylation in health and diseases: molecular mechanisms, biological significance, and clinical implications
2026-07-06
Yue Yang
Signal Transduction and Targeted Therapy, Published online: 06 July 2026; doi:10.1038/s41392-026-02757-7 Protein lactylation in health and diseases: molecular mechanisms, biological significance, and clinical implications]]>
DOI: 10.1038/s41392-026-02757-7Partial downregulation of platelet glycoprotein VI by low affinity antibodies confers sustained and safe antithrombotic protection
2026-07-01
Stefano Navarro
Signal Transduction and Targeted Therapy, Published online: 01 July 2026; doi:10.1038/s41392-026-02864-5 Partial downregulation of platelet glycoprotein VI by low affinity antibodies confers sustained and safe antithrombotic protection]]>
DOI: 10.1038/s41392-026-02864-5Biologics for cardiovascular diseases: from bench to bedside
2026-06-29
Xiaochi Sun
Signal Transduction and Targeted Therapy, Published online: 29 June 2026; doi:10.1038/s41392-026-02673-w Biologics for cardiovascular diseases: from bench to bedside]]>
DOI: 10.1038/s41392-026-02673-wMolecular mechanism of allosteric modulation of opioid receptors
2026-06-26
Heli Wang
Signal Transduction and Targeted Therapy, Published online: 26 June 2026; doi:10.1038/s41392-026-02759-5 Molecular mechanism of allosteric modulation of opioid receptors]]>
DOI: 10.1038/s41392-026-02759-5Potent anti-tumor activity of CD98hc-targeted antibody-drug conjugates in ovarian cancer
2026-06-26
Juan Carlos Montero
Signal Transduction and Targeted Therapy, Published online: 26 June 2026; doi:10.1038/s41392-026-02747-9 Potent anti-tumor activity of CD98hc-targeted antibody-drug conjugates in ovarian cancer]]>
DOI: 10.1038/s41392-026-02747-9Large-scale and high-resolution mass spectrometry-based proteomics defines molecular subtypes of nasopharyngeal carcinoma for therapeutic targeting
2026-06-23
Yi-Ping Wu
Signal Transduction and Targeted Therapy, Published online: 23 June 2026; doi:10.1038/s41392-026-02742-0 Large-scale and high-resolution mass spectrometry-based proteomics defines molecular subtypes of nasopharyngeal carcinoma for therapeutic targeting]]>
DOI: 10.1038/s41392-026-02742-0Activity-dependent antioxidant gene therapy protects against epileptogenesis
2026-06-19
Prince Kumar Singh
Signal Transduction and Targeted Therapy, Published online: 19 June 2026; doi:10.1038/s41392-026-02738-w Activity-dependent antioxidant gene therapy protects against epileptogenesis]]>
DOI: 10.1038/s41392-026-02738-wSpatially interpretable artificial intelligence framework to tailored neoadjuvant dual HER2 blockade in HER2-positive breast cancer
2026-06-19
Xiang-Rong Wu
Signal Transduction and Targeted Therapy, Published online: 19 June 2026; doi:10.1038/s41392-026-02734-0 Spatially interpretable artificial intelligence framework to tailored neoadjuvant dual HER2 blockade in HER2-positive breast cancer]]>
DOI: 10.1038/s41392-026-02734-0Non-receptor tyrosine kinase signaling pathways and therapeutic implications
2026-06-16
MD Anwar Hossain
Signal Transduction and Targeted Therapy, Published online: 16 June 2026; doi:10.1038/s41392-026-02729-x Non-receptor tyrosine kinase signaling pathways and therapeutic implications]]>
DOI: 10.1038/s41392-026-02729-xAKAP1 enhances glycogen accumulation and hepatocarcinogenesis through YTHDF2-mediated G6PC mRNA decay
2026-06-16
Tao Yang
Signal Transduction and Targeted Therapy, Published online: 16 June 2026; doi:10.1038/s41392-026-02733-1 AKAP1 enhances glycogen accumulation and hepatocarcinogenesis through YTHDF2-mediated G6PC mRNA decay]]>
DOI: 10.1038/s41392-026-02733-1Neoadjuvant retlirafusp alfa (anti-PD-L1/TGF-β bifunctional fusion protein) with or without chemotherapy in unresectable stage III non-small cell lung cancer: updated results from the phase 2 TRAILBLAZER trial
2026-06-16
Yi Pan
Signal Transduction and Targeted Therapy, Published online: 16 June 2026; doi:10.1038/s41392-026-02779-1 Neoadjuvant retlirafusp alfa (anti-PD-L1/TGF-β bifunctional fusion protein) with or without chemotherapy in unresectable stage III non-small cell lung cancer: updated results from the phase 2 TRAILBLAZER trial]]>
DOI: 10.1038/s41392-026-02779-1Advancing high-altitude medicine: a model for the future
2026-06-11
Wenjin Sun
Signal Transduction and Targeted Therapy, Published online: 11 June 2026; doi:10.1038/s41392-026-02836-9 Advancing high-altitude medicine: a model for the future]]>
DOI: 10.1038/s41392-026-02836-9Unraveling the HGF/MET axis in Mallory-Denk body pathogenesis associated with liver fibrosis through single-cell transcriptomics
2026-06-11
Xiaoping Tang
Signal Transduction and Targeted Therapy, Published online: 11 June 2026; doi:10.1038/s41392-026-02722-4 Unraveling the HGF/MET axis in Mallory-Denk body pathogenesis associated with liver fibrosis through single-cell transcriptomics]]>
DOI: 10.1038/s41392-026-02722-4Turning the clock: mRNA-encoded thymic factors restore aged immunity
2026-06-08
Muhammad Naveed Khan
Signal Transduction and Targeted Therapy, Published online: 08 June 2026; doi:10.1038/s41392-026-02706-4 Turning the clock: mRNA-encoded thymic factors restore aged immunity]]>
DOI: 10.1038/s41392-026-02706-4Engineering an AIEgen-based platform integrating CRISPR/Cas9 to remodel the tumor microenvironment and reinforce photo-immunotherapy against glioblastom
2026-06-08
Guanghong Luo
Signal Transduction and Targeted Therapy, Published online: 08 June 2026; doi:10.1038/s41392-026-02699-0 Engineering an AIEgen-based platform integrating CRISPR/Cas9 to remodel the tumor microenvironment and reinforce photo-immunotherapy against glioblastom]]>
DOI: 10.1038/s41392-026-02699-0