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61 parsed articles
Last update: 2026-09-22
2026-09-17
Gijs Selten, Florian Lamouche, Adrián Gómez-Repollés, José Luiz López, Xiao-mei Zhang, Caitlan Smart, Zuzana Blahovska, Geovanna Zarate Camargo, Simon Kelly, Ronnie de Jonge, Simona Radutoiu
Functional versatility plays a key role in shaping root microbiota.
DOI: 10.1038/s41564-026-02493-22026-09-17
Elisabet Tintó-Font, Núria Casas-Vila, César Martínez-Guardiola, Alba Pérez-Cantero, Neus Ràfols, Prince B. Nyarko, Alfred Cortés
This study describes the complex transcriptional regulatory mechanism enabling fine-tuned and rapid regulation of Plasmodium falciparum investment in transmission under changing blood conditions.
DOI: 10.1038/s41564-026-02473-62026-09-17
Petra Anne Levin, Jue D. Wang
In this Perspective, Levin and Wang give a brief history of bacterial growth rate and discuss how it is connected to nutrient availability and macromolecule synthesis, with a focus on (p)ppGpp as a central hub regulating resource allocation and, indirectly, growth rate at the single-cell level.
DOI: 10.1038/s41564-026-02449-62026-09-17
Amandine Maire, Monica Ortelli, Emma Tkacz, Christoph Dehio, Benoit Chassaing, Harry Sokol, Nathalie Rolhion, David Bikard
In vivo silencing of genes in E. coli strains using CRISPRi reveals specific genetic factors and metabolic adaptations that influence colonization in the mouse gut under variable physiological conditions.
DOI: 10.1038/s41564-026-02471-82026-09-17
Xiaolei Wu, Teng Wang, Chenghao Jia, Haiyang Zhou, Yan Li, Stephen Baker, Min Yue
Genomic and functional analyses reveal sequential gene loss events affecting dinB and fljB in monophasic Salmonella Typhimurium ST34 conferring a competitive advantage during gut infection and potentially contributing to emergence of this lineage.
DOI: 10.1038/s41564-026-02483-42026-09-16
Min Jin, Victoria A. Jefferson, Zhe Zhao, Nicholas J. Catanzaro, Luca De Sabato, Emma L. Keeler, Bridget L. Menasche, Cameron Hoffman, Boyd L. Yount, Anna Castelli, Ilaria Di Bartolo, Gabriele Vaccari, Tyler N. Starr, Stephanie N. Seifert, Adrian A. Castellanos, Barbara A. Han, Leonid Serebryannyy, Alicen B. Spaulding, Daniel C. Douek, Ana Moreno, Ralph S. Baric, Craig B. Wilen, James M. Rini, Michael Letko
Hedgehog merbecoviruses utilize hedgehog aminopeptidase N, but not the human orthologue, as their entry receptor. Structural resolution of the glycoprotein–receptor interface reveals the molecular interactions underlying this species-specific barrier.
DOI: 10.1038/s41564-026-02447-82026-09-16
Peng Liu, Qianhui Zhu, Jingyi Liu, Zhixing Ma, Guocui Mou, Yuanling Yu, Chen Liu, Chengbao Ma, Junyu Si, Xiao Yang, Meiling Huang, Yanchu Liu, Yehui Sun, Xiao Yu, Yucheng Sun, Tianci Liu, Lingling Yu, Qianran Wang, Honghao Ma, Qi Lv, Jing Li, Linlin Bao, Yunlong Cao, Xiangxi Wang, Huan Yan
Hedgehog merbecoviruses are shown to use aminopeptidase N as a functional receptor through a distinct binding mode, revealing convergent receptor usage among merbecoviruses.
DOI: 10.1038/s41564-026-02478-12026-09-16
Rogerio A. Bataglioli, Hiba Baaziz, Hallie F. Avalos, Lindsay Smith, Zachary R. Baker, Rita J. Makhlouf, David da Silva Barreira, Harsimran Kaur, Teresa Southard, Bryan B. Hsu
An engineered non-pathogenic bacterium produces lytic phages and is protective in mouse models of Salmonella infection.
DOI: 10.1038/s41564-026-02484-32026-07-27
Debajit Dey
Nature Microbiology, Published online: 27 July 2026; doi:10.1038/s41564-026-02424-1 Structural and biochemical follow-up of a serendipitous discovery reveals that Akkermansia muciniphila carbohydrate sulfatases are uniquely adapted to digest colonic mucins in collaboration with other members of gut microbiota.]]>
DOI: 10.1038/s41564-026-02424-12026-07-24
Carolin M. Lieber
Nature Microbiology, Published online: 24 July 2026; doi:10.1038/s41564-026-02419-y Antiviral candidate GHP-88310 provides therapeutic benefit against measles-like disease and protects against productive direct-contact and airborne viral transmission when used for pre- and post-exposure prophylaxis.]]>
DOI: 10.1038/s41564-026-02419-y2026-07-21
D. G. Joakim Larsson
Nature Microbiology, Published online: 21 July 2026; doi:10.1038/s41564-026-02429-w Clarifying objectives to strengthen wastewater-based AMR surveillance]]>
DOI: 10.1038/s41564-026-02429-w2026-07-21
Safi Rehman
Nature Microbiology, Published online: 21 July 2026; doi:10.1038/s41564-026-02425-0 Vasodilation is inhibited by Klebsiella pneumonia through a multipronged approach involving type VI secretion system activity and the VgrG4 effector, plus capsule, to limit eNOS-dependent and endothelial hyperpolarization routes to vasodilation.]]>
DOI: 10.1038/s41564-026-02425-02026-07-20
Iuliia Kotova
Nature Microbiology, Published online: 20 July 2026; doi:10.1038/s41564-026-02416-1 In-cell cross-linking mass spectrometry maps protein contacts in influenza-infected human cells, revealing how the virus hijacks host membrane-trafficking factors and dismantles nuclear paraspeckles to enhance replication.]]>
DOI: 10.1038/s41564-026-02416-12026-07-20
Xin Yu
Nature Microbiology, Published online: 20 July 2026; doi:10.1038/s41564-026-02411-6 Depletion of the vitamin A metabolite all-trans retinoic acid (ATRA) in patients infected with severe fever with thrombocytopenia syndrome virus correlates with severe inflammation. In mice, ATRA supplementation reduces IL-6 levels and hyperinflammation.]]>
DOI: 10.1038/s41564-026-02411-62026-07-06
Mariko Kanai
Nature Microbiology, Published online: 06 July 2026; doi:10.1038/s41564-026-02410-7 A genetic cross of Plasmodium falciparum parasites revealed that quinine resistance is polygenic and is associated with mutations in transporter proteins on chromosome 7 (PfCRT and DMT1) and a metalloprotease on chromosome 12 (FtsH1), highlighting key markers for clinical surveillance.]]>
DOI: 10.1038/s41564-026-02410-72026-06-30
Irene Lepori
Nature Microbiology, Published online: 30 June 2026; doi:10.1038/s41564-026-02412-5 Screening 1,572 compounds for mycomembrane permeation plus cheminformatic and machine learning analyses reveals features associated with improved permeation in the pathogen Mycobacterium tuberculosis and model organism M. smegmatis.]]>
DOI: 10.1038/s41564-026-02412-52026-06-29
Chang Liu
Nature Microbiology, Published online: 29 June 2026; doi:10.1038/s41564-026-02436-x Author Correction: Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids]]>
DOI: 10.1038/s41564-026-02436-x2026-06-24
Xiaoling Li
Nature Microbiology, Published online: 24 June 2026; doi:10.1038/s41564-026-02397-1 Merbecoviruses are genetically diverse betacoronaviruses with cross-species potential and use receptors beyond DPP4 (for example, ACE2 and APN). This Review summarizes recent insights to guide efforts in surveillance, diagnostics and the design of antivirals and vaccines.]]>
DOI: 10.1038/s41564-026-02397-12026-06-23
Staffan Svärd
Nature Microbiology, Published online: 23 June 2026; doi:10.1038/s41564-026-02406-3 Staffan Svärd reflects on his 30-year relationship with Giardia, which has stayed on his mind in a manner reminiscent of its adhesive trophozoite form.]]>
DOI: 10.1038/s41564-026-02406-32026-06-22
Lisa Pagani
Nature Microbiology, Published online: 22 June 2026; doi:10.1038/s41564-026-02390-8 The microbiome plays a significant yet underexplored role in antimicrobial resistance by influencing ecological and evolutionary processes. This Perspective proposes a framework to integrate microbiome–AMR interactions into predictive models while highlighting key mechanisms and data gaps to improve resistance understanding and interventions.]]>
DOI: 10.1038/s41564-026-02390-82026-06-22
Justin C. Deme
Nature Microbiology, Published online: 22 June 2026; doi:10.1038/s41564-026-02399-z Cryo-EM structural, biochemical and functional analyses of the bacterial twin-arginine translocation system for protein transport across membranes reveal mechanisms of substrate binding.]]>
DOI: 10.1038/s41564-026-02399-z2026-06-19
Mercy M. Olorunshola
Nature Microbiology, Published online: 19 June 2026; doi:10.1038/s41564-026-02401-8 Evolved phage cocktails outsmart biofilm defences]]>
DOI: 10.1038/s41564-026-02401-82026-06-19
Marcelo D. T. Torres
Nature Microbiology, Published online: 19 June 2026; doi:10.1038/s41564-026-02408-1 Deep learning reveals that prion-related proteins contain hidden ‘prionin’ peptides with antibacterial activity, including two candidates that reduced infections in mice.]]>
DOI: 10.1038/s41564-026-02408-12026-06-16
Haiyan Zhou
Nature Microbiology, Published online: 16 June 2026; doi:10.1038/s41564-026-02417-0 Author Correction: A clinic-responder-derived defined microbial consortium enhances anti-PD-1 immunotherapy efficacy in mice]]>
DOI: 10.1038/s41564-026-02417-02026-06-15
K. Julia Dierksheide
Nature Microbiology, Published online: 15 June 2026; doi:10.1038/s41564-026-02389-1 Purine bias is critical for gene expression in bacteria, preventing premature transcription in species that exhibit runaway transcription.]]>
DOI: 10.1038/s41564-026-02389-12026-06-12
Xiaofang Wang
Nature Microbiology, Published online: 12 June 2026; doi:10.1038/s41564-026-02373-9 Phage–bacteria coevolution is associated with field-specific anti-phage defence and locally adapted phage populations, resulting in phage-resistant but weakly virulent pathogens.]]>
DOI: 10.1038/s41564-026-02373-92026-06-12
Lina Widerspick
Nature Microbiology, Published online: 12 June 2026; doi:10.1038/s41564-026-02388-2 In a cerebral organoid model, Ebola virus persists by infecting neurons, astrocytes and microglia, driving local inflammation, cell-specific responses, viral adaptation and cell-to-cell spread.]]>
DOI: 10.1038/s41564-026-02388-22026-06-12
Tong Zhang
Nature Microbiology, Published online: 12 June 2026; doi:10.1038/s41564-026-02384-6 The activation of an antiphage defence system relies on host factors targeted by phages, a mechanism analogous to the way that eukaryotic innate immune systems detect pathogen-induced perturbations of host cells through effector-triggered immunity.]]>
DOI: 10.1038/s41564-026-02384-62026-06-10
Xinyu Liang
Nature Microbiology, Published online: 10 June 2026; doi:10.1038/s41564-026-02381-9 Higher lipid intake in mice causes damage to goblet cells with depletion of Akkermansia muciniphila and increase in Clostridium scindens abundance, which produces secondary bile acids that activate pathways driving increased intestinal fat absorption.]]>
DOI: 10.1038/s41564-026-02381-92026-06-04
Nature Microbiology, Published online: 04 June 2026; doi:10.1038/s41564-026-02396-2 Effective science communication can help scientists shape impactful research questions, and crucially it can foster curiosity, showcase the importance of research and encourage support and engagement from non-scientists.]]>
DOI: 10.1038/s41564-026-02396-2