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Nature Microbiology

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8 parsed articles

Last update: 2026-09-21

Latest articles

Aminopeptidase N is a receptor for hedgehog merbecoviruses

2026-09-16

Min Jin, Victoria A. Jefferson, Zhe Zhao, Nicholas J. Catanzaro, Luca De Sabato, Emma L. Keeler, Bridget L. Menasche, Cameron Hoffman, Boyd L. Yount, Anna Castelli, Ilaria Di Bartolo, Gabriele Vaccari, Tyler N. Starr, Stephanie N. Seifert, Adrian A. Castellanos, Barbara A. Han, Leonid Serebryannyy, Alicen B. Spaulding, Daniel C. Douek, Ana Moreno, Ralph S. Baric, Craig B. Wilen, James M. Rini, Michael Letko

Hedgehog merbecoviruses utilize hedgehog aminopeptidase N, but not the human orthologue, as their entry receptor. Structural resolution of the glycoprotein–receptor interface reveals the molecular interactions underlying this species-specific barrier.

DOI: 10.1038/s41564-026-02447-8

Convergent use of aminopeptidase N receptor by hedgehog merbecoviruses

2026-09-16

Peng Liu, Qianhui Zhu, Jingyi Liu, Zhixing Ma, Guocui Mou, Yuanling Yu, Chen Liu, Chengbao Ma, Junyu Si, Xiao Yang, Meiling Huang, Yanchu Liu, Yehui Sun, Xiao Yu, Yucheng Sun, Tianci Liu, Lingling Yu, Qianran Wang, Honghao Ma, Qi Lv, Jing Li, Linlin Bao, Yunlong Cao, Xiangxi Wang, Huan Yan

Hedgehog merbecoviruses are shown to use aminopeptidase N as a functional receptor through a distinct binding mode, revealing convergent receptor usage among merbecoviruses.

DOI: 10.1038/s41564-026-02478-1