2026-09-17
Gijs Selten, Florian Lamouche, Adrián Gómez-Repollés, José Luiz López, Xiao-mei Zhang, Caitlan Smart, Zuzana Blahovska, Geovanna Zarate Camargo, Simon Kelly, Ronnie de Jonge, Simona Radutoiu
Functional versatility plays a key role in shaping root microbiota.
DOI: 10.1038/s41564-026-02493-22026-09-17
Elisabet Tintó-Font, Núria Casas-Vila, César Martínez-Guardiola, Alba Pérez-Cantero, Neus Ràfols, Prince B. Nyarko, Alfred Cortés
This study describes the complex transcriptional regulatory mechanism enabling fine-tuned and rapid regulation of Plasmodium falciparum investment in transmission under changing blood conditions.
DOI: 10.1038/s41564-026-02473-62026-09-17
Petra Anne Levin, Jue D. Wang
In this Perspective, Levin and Wang give a brief history of bacterial growth rate and discuss how it is connected to nutrient availability and macromolecule synthesis, with a focus on (p)ppGpp as a central hub regulating resource allocation and, indirectly, growth rate at the single-cell level.
DOI: 10.1038/s41564-026-02449-62026-09-17
Amandine Maire, Monica Ortelli, Emma Tkacz, Christoph Dehio, Benoit Chassaing, Harry Sokol, Nathalie Rolhion, David Bikard
In vivo silencing of genes in E. coli strains using CRISPRi reveals specific genetic factors and metabolic adaptations that influence colonization in the mouse gut under variable physiological conditions.
DOI: 10.1038/s41564-026-02471-82026-09-17
Xiaolei Wu, Teng Wang, Chenghao Jia, Haiyang Zhou, Yan Li, Stephen Baker, Min Yue
Genomic and functional analyses reveal sequential gene loss events affecting dinB and fljB in monophasic Salmonella Typhimurium ST34 conferring a competitive advantage during gut infection and potentially contributing to emergence of this lineage.
DOI: 10.1038/s41564-026-02483-42026-09-16
Min Jin, Victoria A. Jefferson, Zhe Zhao, Nicholas J. Catanzaro, Luca De Sabato, Emma L. Keeler, Bridget L. Menasche, Cameron Hoffman, Boyd L. Yount, Anna Castelli, Ilaria Di Bartolo, Gabriele Vaccari, Tyler N. Starr, Stephanie N. Seifert, Adrian A. Castellanos, Barbara A. Han, Leonid Serebryannyy, Alicen B. Spaulding, Daniel C. Douek, Ana Moreno, Ralph S. Baric, Craig B. Wilen, James M. Rini, Michael Letko
Hedgehog merbecoviruses utilize hedgehog aminopeptidase N, but not the human orthologue, as their entry receptor. Structural resolution of the glycoprotein–receptor interface reveals the molecular interactions underlying this species-specific barrier.
DOI: 10.1038/s41564-026-02447-82026-09-16
Peng Liu, Qianhui Zhu, Jingyi Liu, Zhixing Ma, Guocui Mou, Yuanling Yu, Chen Liu, Chengbao Ma, Junyu Si, Xiao Yang, Meiling Huang, Yanchu Liu, Yehui Sun, Xiao Yu, Yucheng Sun, Tianci Liu, Lingling Yu, Qianran Wang, Honghao Ma, Qi Lv, Jing Li, Linlin Bao, Yunlong Cao, Xiangxi Wang, Huan Yan
Hedgehog merbecoviruses are shown to use aminopeptidase N as a functional receptor through a distinct binding mode, revealing convergent receptor usage among merbecoviruses.
DOI: 10.1038/s41564-026-02478-12026-09-16
Rogerio A. Bataglioli, Hiba Baaziz, Hallie F. Avalos, Lindsay Smith, Zachary R. Baker, Rita J. Makhlouf, David da Silva Barreira, Harsimran Kaur, Teresa Southard, Bryan B. Hsu
An engineered non-pathogenic bacterium produces lytic phages and is protective in mouse models of Salmonella infection.
DOI: 10.1038/s41564-026-02484-3