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8 parsed articles
Last update: 2026-09-21
2026-09-18
Aging is associated with myeloid-biased hematopoiesis, which leads to the establishment of a pro-inflammatory microenvironment. We discovered that cytotoxic CD4+ T cells foster this process via the CCL5–CCR5 axis and found that the clinically approved CCR5 antagonist maraviroc can rebalance immunity in aged mice.
DOI: 10.1038/s43587-026-01241-92026-09-16
Arturo D’Angelo, Daniel Franco-Barranco, Marco Musy, Juan Manuel Duran, James Sharpe, Nicholas Stroustrup, Ignacio Arganda-Carreras, Elvan Böke
DOI: 10.1038/s43587-026-01244-62026-09-14
Brendan Miller, Eduardo Vieira de Souza, Calvin Lau, Joan M. Vaughan, Victor J. Pai, Servando Giraldez, Andréa Rocha, Jolene K. Diedrich, Clodagh C. O’Shea, David A. Bennett, Alan Saghatelian
A new atlas identifies 1,067 unannotated microproteins in the human frontal cortex with strong spectral grades. A subset is differentially expressed in Alzheimer’s disease independently of their canonical genes, including an MKKS-derived microprotein required for normal microglial mitochondrial respiration.
DOI: 10.1038/s43587-026-01207-x2026-09-14
Microproteins, small proteins of 100–150 amino acids, are largely absent from reference proteomes and have been overlooked in brain and aging research. An atlas of the aged human brain catalogs over 1,000 high-confidence microproteins, including one encoded by the MKKS gene that is reduced in Alzheimer’s disease and regulates energy production in microglia.
DOI: 10.1038/s43587-026-01215-x2026-09-11
Prabesh Bhattarai, Elanur Yilmaz, Elif Öykü Cakir, Huseyin Tayran, Imdadul Haq, Dylan Murphy, Jonah Nadelmann Keller, Quentin Le Grand, Jacqueline O. Eschbach, Hilal Celikkaya, Mehmet I. Cosacak, Hande Yüceer Korkmaz, Annie J. Lee, Verena Haage, Yiyi Ma, Xue Wang, Nastasia Nelson, Weilin Lin, Yixin Zhang, Bengisu Turgutalp, Sherida M. de Leeuw, Ronak Patel, Dörthe Jülich, Özkan İş, Scott A. Holley, Philip L. De Jager, Uwe Freudenberg, Carsten Werner, Peter St George-Hyslop, Nilüfer Ertekin-Taner, Stéphanie Debette, Fanny M. Elahi, Elizabeth S. Fisher, Hemali Phatnani, Andrew F. Teich, Kate Tubbesing, Taylor Bertucci, Sally Temple, Tal Nuriel, Badri N. Vardarajan, Richard Mayeux, Caghan Kizil
Bhattarai, Yilmaz and colleagues identify astrocyte-derived fibronectin as a key driver of blood–brain barrier dysfunction in Alzheimer’s disease, linking APOE ε4 and amyloid pathology to vascular damage and highlighting FN1 as a potential therapeutic target.
DOI: 10.1038/s43587-026-01204-02026-09-11
Orsolya Symmons
DOI: 10.1038/s43587-026-01193-02026-09-07
Joseph L. Dieleman
Ashwin and colleagues propose a statistical framing of the epidemiological transition that categorizes global diseases into four life-stages, identifying aging-related diseases as the dominant category. As aging-related diseases tend to cluster and span many years, health systems must pivot from treating disease to preserving health through investments in all life stages.
DOI: 10.1038/s43587-026-01218-82026-09-07
Hongkai Zhao, Qianzhao Ji, Zeming Wu, Si Wang, Jie Ren, Kaowen Yan, Zehua Wang, Jianli Hu, Qun Chu, Huifang Hu, Yusheng Cai, Qiaoran Wang, Daoyuan Huang, Zhejun Ji, Jingyi Li, Juan Carlos Izpisua Belmonte, Moshi Song, Weiqi Zhang, Jing Qu, Guang-Hui Liu
DOI: 10.1038/s43587-026-01235-7