2026-10-22
This PrimeView highlights the diagnosis of Birt-Hogg-Dubé syndrome, a tumour predisposition disorder caused by pathogenic variants in the folliculin gene, and summarized its epidemiology, mechanisms and management. It accompanies the Primer on this topic by Marciniak et al..
DOI: 10.1038/s41572-026-00753-32026-10-22
Stefan J. Marciniak, Andrea Ballabio, Elizabeth P. Henske, John C. Kennedy, W. Marston Linehan, Eamonn R. Maher, Neil Rajan, Maria T. Wetscherek, Kai-Feng Xu
Birt–Hogg–Dubé syndrome is an autosomal dominant tumour predisposition disorder caused by pathogenic variants in the gene encoding folliculin. In this Primer, Marciniak et al. describe the epidemiology, mechanisms, diagnosis and management of Birt–Hogg–Dubé syndrome, and highlight patients’ quality of life, and questions for future research.
DOI: 10.1038/s41572-026-00745-32026-10-15
This PrimeView highlights the epidemiology of dengue virus infection, and summarizes the pathophysiology, diagnosis, prevention and management of this disease. It accompanies the Primer on this topic by Ooi et al.
DOI: 10.1038/s41572-026-00749-z2026-10-15
Yaw Shin Ooi, Jonathan Cattrall, Oliver Brady, Shirin Kalimuddin, Jue Tao Lim, Eduardo Lopez-Medina, Stephen J. Thomas, Sophie Yacoub, Eng Eong Ooi
Dengue is an acute febrile disease caused by the Aedes mosquito-borne dengue viruses. In this Primer, Ooi et al. describe the epidemiology, mechanisms, diagnosis and management of dengue infection and highlight patients’ quality of life and questions for future research.
DOI: 10.1038/s41572-026-00744-42026-10-08
This PrimeView highlights the mechanisms of Tourette syndrome and accompanies the Primer on this condition by Eapen et al.
DOI: 10.1038/s41572-026-00748-02026-10-08
Valsamma Eapen, Harvey S. Singer, Carol A. Mathews, Davide Martino, Jennifer Vermilion, Andrea E. Cavanna, Peristera Paschou
Tourette syndrome is a neurodevelopmental disorder characterized by motor and vocal tics. This Primer discusses the epidemiology, mechanisms, diagnosis and treatment of Tourette syndrome.
DOI: 10.1038/s41572-026-00742-62026-10-01
This PrimeView highlights the epidemiology, pathophysiology, diagnosis, management and quality of life of individuals with irritable bowel syndrome.
DOI: 10.1038/s41572-026-00747-12026-10-01
Lin Chang, Maura Corsetti, William D. Chey, Alexander C. Ford, Max J. Schmulson, Andrea Shin, Giovanni Barbara, Sarah Ballou, Emeran A. Mayer, Kewin T. Siah, Magnus Simrén, Heidi Staudacher, Anthony J. Lembo
In this Primer, Chang and colleagues review the epidemiology, pathophysiology, diagnosis and management of irritable bowel syndrome (IBS) as well as the quality of life of individuals with IBS — a prevalent disorder of gut–brain interaction characterized by recurrent abdominal pain or discomfort associated with altered bowel habits.
DOI: 10.1038/s41572-026-00741-72026-07-09
Nature Reviews Disease Primers, Published online: 09 July 2026; doi:10.1038/s41572-026-00725-7 This PrimeView highlights the mechanisms of the thalassaemia syndromes. The PrimeView also summarizes the epidemiology, diagnosis and outlook of the thalassaemia syndromes.]]>
DOI: 10.1038/s41572-026-00725-72026-06-25
Karl N. Fai
Nature Reviews Disease Primers, Published online: 25 June 2026; doi:10.1038/s41572-026-00720-y Buruli ulcer in Africa: between innovation and pragmatism]]>
DOI: 10.1038/s41572-026-00720-y2026-06-18
Jennifer B. Reese
Nature Reviews Disease Primers, Published online: 18 June 2026; doi:10.1038/s41572-026-00712-y Cancer and chronic illnesses and their treatments negatively impact patients’ sexual health yet sexual issues are inadequately addressed in healthcare, often due to societal taboo and inadequate clinician training. Sexual health is part of overall well-being and should be integrated into whole-person medical care using a biopsychosocial model.]]>
DOI: 10.1038/s41572-026-00712-y2026-06-04
Stephan Weidinger
Nature Reviews Disease Primers, Published online: 04 June 2026; doi:10.1038/s41572-026-00703-z Atopic dermatitis is the most common inflammatory skin disease. In this Primer, Weidinger and colleagues describe the epidemiology of this condition, discuss its mechanisms, diagnosis and management, and highlight patients’ quality of life and questions for future research.]]>
DOI: 10.1038/s41572-026-00703-z2026-05-28
Nature Reviews Disease Primers, Published online: 28 May 2026; doi:10.1038/s41572-026-00715-9 This PrimeView highlights the epidemiology, pathophysiolpogy, diagnosis, management and quality of life of individuals with osteomyelitis, an infection of the bone caused primarily by bacteria.]]>
DOI: 10.1038/s41572-026-00715-92026-05-14
Nature Reviews Disease Primers, Published online: 14 May 2026; doi:10.1038/s41572-026-00709-7 This PrimeView highlights the mechanisms of post-traumatic stress disorder and accompanies the Primer on this disorder by Ressler and colleagues.]]>
DOI: 10.1038/s41572-026-00709-72026-04-30
Nature Reviews Disease Primers, Published online: 30 April 2026; doi:10.1038/s41572-026-00705-x This PrimeView highlights the mechanisms of necrotizing enterocolitis and accompanies the Primer on this disease by Hackman and colleagues.]]>
DOI: 10.1038/s41572-026-00705-x2026-04-16
Nature Reviews Disease Primers, Published online: 16 April 2026; doi:10.1038/s41572-026-00700-2 This PrimeView highlights the mechanisms underlying VEXAS syndrome, and summarizes the epidemiology, diagnosis and management of the condition. It accompanies the Primer on this topic by Beck et al.]]>
DOI: 10.1038/s41572-026-00700-22026-04-09
Kai Spiegelhalder
Nature Reviews Disease Primers, Published online: 09 April 2026; doi:10.1038/s41572-026-00693-y This Primer by Riemann and colleagues summarizes the epidemiology, diagnosis, treatment and pathophysiology of insomnia disorder.]]>
DOI: 10.1038/s41572-026-00693-y2026-04-09
Nature Reviews Disease Primers, Published online: 09 April 2026; doi:10.1038/s41572-026-00697-8 This PrimeView highlights the diagnosis of insomnia disorder and accompanies the Primer on this topic by Riemann et al.]]>
DOI: 10.1038/s41572-026-00697-82026-03-12
Kellen Winden, E. Martina Bebin, Shafali Jeste, Darcy A. Krueger, Elahna Paul, Mustafa Sahin
Nature Reviews Disease Primers, Published online: 12 March 2026; doi:10.1038/s41572-026-00688-9 This Primer by Sahin and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of tuberous sclerosis complex.
2026-03-05
Clare L. Scott, Susana Banerjee, Florence Joly, Jung-Min Lee, Asima Mukhopadhyay, David S. Tan, Elise C. Kohn
Nature Reviews Disease Primers, Published online: 05 March 2026; doi:10.1038/s41572-026-00686-x Ovarian cancer comprises a group of malignancies of epithelial origin that have distinct pathogeneses, histologies and prognoses. In this Primer, Scott et al. discuss epidemiology and risk factors, mechanisms, diagnosis and management of ovarian cancer subtypes, and highlight patient quality of life and areas for future research.