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49 parsed articles
Last update: 2026-09-22
2026-09-21
Tao Jiang, Heng Hu, Runtian Gao, Shuqi Cao, Zhongjun Jiang, Murong Zhou, Wentao Gao, Shengming Zhou, Guohua Wang
SVPG performs accurate pangenome-facilitated structural variant detection and accelerates pangenome graph augmentation using long-read sequencing data.
DOI: 10.1038/s41592-026-03219-22026-09-16
Vivien Marx
Prototypes of specially engineered transmission electron microscopes deliver images with greatly improved contrast to cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) projects.
DOI: 10.1038/s41592-026-03239-y2026-09-16
Helena Klara Jambor, Fateme Rajabiyazdi, Verena Prantl, Matthias Flotho, Torsten Möller, Cagatay Turkay
Some visualizations resonate while others are forgotten. Why that is can be understood with the principles of creating ‘proximity’.
DOI: 10.1038/s41592-026-03241-42026-09-14
Tony Chen, Haoyu Zhang, Rahul Mazumder, Xihong Lin
Rather than relying on pre-specified ancestry labels, which often fail to capture the full genetic heterogeneity of diverse populations, SPLENDID treats ancestry as a continuum and improves polygenic risk score (PRS) prediction for biobank-scale datasets.
DOI: 10.1038/s41592-026-03235-22026-09-14
Fatemeh Abbasi, Katharina Rieck, Matthias Brandt, Maja Matis, Eva Kiermaier, Timo Betz
CFM enables tunable cell confinement for measuring traction forces exerted by single cells and cell aggregates in tissue-mimicking microenvironments.
DOI: 10.1038/s41592-026-03216-52026-09-11
Giang N. T. Le, Lam M. T. Pham, Boyan Xue, Maruti Uppalapati, G. Andrew Woolley
A compact protein pair that heterodimerizes upon red light activation, FenixS and Ash1, is developed for optogenetic applications.
DOI: 10.1038/s41592-026-03223-62026-09-10
Studying the brain mechanisms of natural behaviors is experimentally challenging. We developed a miniaturized, wireless platform to record and manipulate neural and physiological activity in small animals, enabling the study of neural mechanisms underlying rodent social group behaviors across laboratory and outdoor natural environments.
DOI: 10.1038/s41592-026-03221-82026-09-10
Zifang Zhao, Hongyu Chang, Praveen Paudel, Jaehyo Park, Can Liu, Maria Q. Aurelio, Azahara Oliva, Antonio Fernandez-Ruiz
WILD is a wireless device that can record neuronal activity, perform optogenetic stimulations, record animal movements, record the environment or eye movements via an integrated camera, analyze the data and trigger optogenetic stimulation. This device facilitates studies of brain activity in freely moving animals such as mice, both in the laboratory and under naturalistic conditions.
DOI: 10.1038/s41592-026-03220-92026-09-08
Vivien Marx
Many have dreamt of studying and getting their scientific training in the United States. These days, that dream is no easy pursuit.
DOI: 10.1038/s41592-026-03240-52026-07-27
Peter Rupprecht
Nature Methods, Published online: 27 July 2026; doi:10.1038/s41592-026-03183-x In this Analysis, Rupprecht et al. investigate the behavior of GCaMP8 variants in spike inference using several different algorithms. They highlight the role of the indicators’ linearity in the inference process.]]>
DOI: 10.1038/s41592-026-03183-x2026-07-27
Vivien Marx
Nature Methods, Published online: 27 July 2026; doi:10.1038/s41592-026-03171-1 Groups of immunologists are advancing recommendations to address nomenclature challenges in their subfields.]]>
DOI: 10.1038/s41592-026-03171-12026-07-24
Helena Mannochio-Russo
Nature Methods, Published online: 24 July 2026; doi:10.1038/s41592-026-03186-8 Bridging complexity and accessibility in metabolomics with MetaboApps]]>
DOI: 10.1038/s41592-026-03186-82026-07-24
Hengxin Liu
Nature Methods, Published online: 24 July 2026; doi:10.1038/s41592-026-03174-y Fullscope-seq combines a spatial transcriptomics approach (Stereo-seq) with long-read sequencing. The approach provides isoform information at single-cell resolution across a large field of view, as demonstrated on macaque brain slices.]]>
DOI: 10.1038/s41592-026-03174-y2026-07-23
Jingkun Guo
Nature Methods, Published online: 23 July 2026; doi:10.1038/s41592-026-03158-y FlatMux is an optimized microscope system for multiplexed two-photon imaging of neuronal activity with genetically encoded voltage sensors. The flexible system is demonstrated in a variety of scenarios in the mouse brain including a large field of view, deep imaging or two-plane imaging.]]>
DOI: 10.1038/s41592-026-03158-y2026-07-21
Qinhao Cao
Nature Methods, Published online: 21 July 2026; doi:10.1038/s41592-026-03163-1 This Article introduces a phospho-switch for allosterically regulating target proteins in response to ERK kinase activity.]]>
DOI: 10.1038/s41592-026-03163-12026-07-20
Timo Dickscheid
Nature Methods, Published online: 20 July 2026; doi:10.1038/s41592-026-03159-x Siibra is a software suite for working with diverse human brain atlases. It links data acquired with different modalities and at different resolution, thereby creating a Multilevel Human Brain Atlas.]]>
DOI: 10.1038/s41592-026-03159-x2026-07-10
Carlo Bevilacqua
Nature Methods, Published online: 10 July 2026; doi:10.1038/s41592-026-03164-0 Towards a standardized file format and open-source analysis framework for Brillouin microscopy data]]>
DOI: 10.1038/s41592-026-03164-02026-07-09
Vivien Marx
Nature Methods, Published online: 09 July 2026; doi:10.1038/s41592-026-03145-3 Civil war, mass killings, humanitarian crises are reasons aplenty to abandon science. But geneticist Amna Khidir and Nile University–Sudan chose to continue in science.]]>
DOI: 10.1038/s41592-026-03145-32026-07-09
Nina Vogt
Nature Methods, Published online: 09 July 2026; doi:10.1038/s41592-026-03168-w Circuit manipulation with gap junctions]]>
DOI: 10.1038/s41592-026-03168-w2026-07-09
Aparna Anantharaman
Nature Methods, Published online: 09 July 2026; doi:10.1038/s41592-026-03166-y Glycan atlasing in cells and tissues]]>
DOI: 10.1038/s41592-026-03166-y2026-07-09
Helena Klara Jambor
Nature Methods, Published online: 09 July 2026; doi:10.1038/s41592-026-03147-1 Biological figures increasingly originate in the browser.]]>
DOI: 10.1038/s41592-026-03147-12026-06-29
Jianing Gao
Nature Methods, Published online: 29 June 2026; doi:10.1038/s41592-026-03151-5 Spatio-DARLIN combines the DARLIN mouse model with sequencing-based spatial transcriptomics to enable high-resolution spatial lineage tracing in mice.]]>
DOI: 10.1038/s41592-026-03151-52026-06-22
Janaka Senarathna
Nature Methods, Published online: 22 June 2026; doi:10.1038/s41592-026-03111-z A miniscope with cloud-based operation and multicontrast capabilities enables continuous recording of neuronal activity, hemodynamics or cellular dynamics over multiple days. This allows monitoring brain function in neurological disease models for example undergoing seizures or harboring brain tumors.]]>
DOI: 10.1038/s41592-026-03111-z2026-06-15
Xiao Wang
Nature Methods, Published online: 15 June 2026; doi:10.1038/s41592-026-03097-8 HiCFoundation is a foundation model pretrained on a large corpus of Hi-C data for comprehensive 3D genome and epigenomics analysis.]]>
DOI: 10.1038/s41592-026-03097-82026-06-15
Nature Methods, Published online: 15 June 2026; doi:10.1038/s41592-026-03098-7 We developed a foundation model for 3D genome organization from Hi-C-derived chromatin structure. HiCFoundation supports integrative analysis linking genome architecture to downstream regulatory function. Through large-scale self-supervised pretraining on Hi-C data, followed by fine-tuning on downstream tasks, it provides a unified, efficient, generalizable and interpretable paradigm for 3D genome, single-cell and multiomics analysis across species.]]>
DOI: 10.1038/s41592-026-03098-72026-06-15
Sean L. Meharry
Nature Methods, Published online: 15 June 2026; doi:10.1038/s41592-026-03130-w Search, organize, aggregate and share image data with BioFile Finder (BFF)]]>
DOI: 10.1038/s41592-026-03130-w2026-06-12
Dejan Lazarević
Nature Methods, Published online: 12 June 2026; doi:10.1038/s41592-026-03139-1 The m6A-ARTR-DBiT technique allows the spatial profiling of m6A mRNA modifications.]]>
DOI: 10.1038/s41592-026-03139-12026-06-11
Fariha Rahman
Nature Methods, Published online: 11 June 2026; doi:10.1038/s41592-026-03132-8 Capturing single nucleosome architectures at scale]]>
DOI: 10.1038/s41592-026-03132-82026-06-11
Nature Methods, Published online: 11 June 2026; doi:10.1038/s41592-026-03143-5 This month, we reintroduce the Points of View column, with updated practical advice for visualizing scientific data.]]>
DOI: 10.1038/s41592-026-03143-52026-06-09
Alexandr Klioutchnikov
Nature Methods, Published online: 09 June 2026; doi:10.1038/s41592-026-03125-7 A lightweight head-mounted multiplane microscope allows simultaneous imaging from >1,800 neurons spread across the cortical layers in freely moving mice performing complex behavioral tasks, sampled over weeks.]]>
DOI: 10.1038/s41592-026-03125-7