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22 parsed articles
Last update: 2026-10-23
2026-10-22
Raffaele Nicastro, Laura Brohée, Josephine Alba, Julian Nüchel, Gianluca Figlia, Stefanie Kipschull, Peter Gollwitzer, Jesus Romero-Pozuelo, Stephanie A. Fernandes, Andreas Lamprakis, Stefano Vanni, Aurelio A. Teleman, Claudio De Virgilio, Constantinos Demetriades
DOI: 10.1038/s41556-026-02132-22026-10-22
Sarah N. Steiner, Eric N. Horst, Evelyn S. Chiu, Mitre Athaiya, Craig N. Johnson, Joseph Y. Shen, Michelle L. Kerns, Joseph D. Kirma, Rebecca L. McCarthy, Syed F. H. Shah, Ofer Sarig, Liat Samuelov, Eli Sprecher, Edel A. O’Toole, Johann E. Gudjonsson, Geeta Mehta, Ramiro Iglesias-Bartolome, Pierre A. Coulombe
Steiner et al. propose that keratin 9 (K9) interacts with 14-3-3, sequestering YAP1 in the cytoplasm and inhibiting YAP1 activity. They identify dysregulated YAP in palmoplantar keratinization diseases, with K9 as a downstream regulator of YAP.
DOI: 10.1038/s41556-026-02087-42026-10-21
Jianping He, Mackenzie Kelleher, Geraldine Veeckmans, Yuezhong Zhang, Luke Reynolds, Hannah M. Tanczos, Zhengrong Huang, Brett P. McLaughlin, Mary Ann Martinez Molina, Ava Lightburn, Mira Zamarro, Wesley Huang, Stephenson B. Owusu, Magali Walravens, Cyril Willemart, Behrouz Hassannia, Lauren E. Pope, Christopher Gager, Alec J. Vaughan, Zhe Wang, Simon Weaver, William Boggess, Xin Lu, Thales Papagiannakopoulos, Ana Lidia Flores-Mireles, Parakkal Deepak, Matthew A. Ciorba, Bryan G. Allen, John M. Buatti, Michael S. Petronek, Scott J. Dixon, Tom Vanden Berghe, Yatrik M. Shah, Zachary T. Schafer
He et al. report the upregulation of a reducing reagent-resistant form of the transferrin receptor 1 dimer during lipid peroxidation and demonstrate its utility in detecting ferroptosis in tissue lysates and extracellular vesicles from mice and humans.
DOI: 10.1038/s41556-026-02107-32026-10-20
Leoti Jiawei Wang, Huajian Yang, Jinzhu Song, Rusong Zhao, Shiyu Liu, Hua Hou, Chuanxin Zhang, Hao Tian, Jiayin Gao, Jun Chen, Zi-Jiang Chen, Han Zhao, Boyang Liu, Keliang Wu
Wang et al. map a Carnegie stage 12 human embryo with spatial transcriptomics and metabolomics.
DOI: 10.1038/s41556-026-02086-52026-10-19
Xiao Jiang, Weizhi He, Chu Xu, Wanwei Zheng, Chenye Li, Danhua Xu, Qixin Shao, Yin Li, Zhuo Liu, Wenshuai Li, Shuang He, Zhiqiang Wang, Ronghua Liu, Yiwei Chu, Zhongguang Luo, Xinxin Huang, Jie Liu, Enzhuo Yang, Lulu Hu
Jiang, He, Xu, Zheng et al. report a functional role for cell-surface Y RNAs in modulating extracellular histone-induced inflammatory signalling and cytokine secretion, which may contribute to the pathogenesis of inflammatory bowel disease.
DOI: 10.1038/s41556-026-02100-w2026-10-16
Esther Rodríguez-Correa, Florian Grünschläger, Tamar Nizharadze, Natasha Anstee, Jude Al-Sabah, Vojtech Kumpost, Anastasia Sedlmeier, Congxin Li, Melanie Ball, Foteini Fotopoulou, Jeyan Jayarajan, Ian Ghezzi, Julia Knoch, Megan Druce, Kleo Aurich, Marleen Büchler-Schäff, Susanne Lux, Pablo Hernández-Malmierca, Julius Gräsel, Dominik Vonficht, Marta López-Osias, Elvira González-Saiz, Daniel Fernández-Pérez, Anna Mathioudaki, Judith Zaugg, Alejo Rodríguez-Fraticelli, Ralf Mikut, Andreas Trumpp, Thomas Höfer, Daniel Hübschmann, Simon Haas, Michael D. Milsom
DOI: 10.1038/s41556-026-02103-72026-10-15
Yao Zhang, Katrin Strassburger, Aurelio A. Teleman
DOI: 10.1038/s41556-026-02104-62026-10-12
Sung Min Son, So Jung Park, Sophia Y. Breusegem, Delphine Larrieu, David C. Rubinsztein
DOI: 10.1038/s41556-026-02120-62026-07-27
Binwu Tang
Nature Cell Biology, Published online: 27 July 2026; doi:10.1038/s41556-026-02013-8 Using a dynamic fluorescent reporter, Tang et al. demonstrate that cancer stem cells are hyper-responsive to microenvironmental cues, which they sense and adapt to through YAP/TAZ signalling, thereby playing an essential role in breast cancer lung metastasis.]]>
DOI: 10.1038/s41556-026-02013-82026-07-24
Veronica J. Farmer
Nature Cell Biology, Published online: 24 July 2026; doi:10.1038/s41556-026-02012-9 In this Comment, we call on scientists to share their stories. Through casual conversation or prepared presentations, with images or essays, scientists can advocate for their research and reach taxpayers and elected officials at a time when science funding and public trust are undermined, particularly in the USA.]]>
DOI: 10.1038/s41556-026-02012-92026-07-20
Yuanchun Luo
Nature Cell Biology, Published online: 20 July 2026; doi:10.1038/s41556-026-02010-x Luo et al. describe a budding type of lysosome fission linked to delivery of MFF from mitochondrial-derived vesicles to lysosomes. MFF recruits DRP1 for membrane scission. This axis restores lysosome function during hypoxia–reoxygenation stress.]]>
DOI: 10.1038/s41556-026-02010-x2026-07-13
Petra Gross
Nature Cell Biology, Published online: 13 July 2026; doi:10.1038/s41556-026-02026-3 Cargo capture during ER-phagy]]>
DOI: 10.1038/s41556-026-02026-32026-07-08
Dohun Kim
Nature Cell Biology, Published online: 08 July 2026; doi:10.1038/s41556-026-02004-9 This Review discusses the spatial organization of nucleotide metabolism and its integration with cellular signalling pathways, emphasizing its importance as a dynamic regulatory axis in both physiological contexts and disease.]]>
DOI: 10.1038/s41556-026-02004-92026-06-26
Nature Cell Biology, Published online: 26 June 2026; doi:10.1038/s41556-026-02008-5 The exact routes and mechanisms of iron acquisition by mitochondria are unclear. We identify mitochondria–endoplasmic reticulum contact sites as an iron supply hub and reveal that the mitochondrial ubiquitin ligase MITOL regulates HMOX2 activity, to enable delivery of haem-derived iron to sustain mitochondrial iron homeostasis.]]>
DOI: 10.1038/s41556-026-02008-52026-06-17
Xiaohui Zhang
Nature Cell Biology, Published online: 17 June 2026; doi:10.1038/s41556-026-02001-y Author Correction: Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain]]>
DOI: 10.1038/s41556-026-02001-y2026-06-16
Yanzhu Yue
Nature Cell Biology, Published online: 16 June 2026; doi:10.1038/s41556-026-02011-w Author Correction: Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution]]>
DOI: 10.1038/s41556-026-02011-w2026-06-15
Zhe Wang
Nature Cell Biology, Published online: 15 June 2026; doi:10.1038/s41556-026-01990-0 Spatial profiling in bladder cancer]]>
DOI: 10.1038/s41556-026-01990-02026-06-15
Guang Peng
Nature Cell Biology, Published online: 15 June 2026; doi:10.1038/s41556-026-01997-7 Author Correction: BRIT1/MCPH1 links chromatin remodelling to DNA damage response]]>
DOI: 10.1038/s41556-026-01997-72026-06-11
Sifan Rong
Nature Cell Biology, Published online: 11 June 2026; doi:10.1038/s41556-026-01993-x This Perspective highlights the use of current proteomics technologies in defining stage-specific reprogramming events to understand reproductive ageing, improve oocyte quality, and refine the outcomes of assisted reproductive technology (ART).]]>
DOI: 10.1038/s41556-026-01993-x2026-03-30
Nature Cell Biology, Published online: 30 March 2026; doi:10.1038/s41556-026-01932-w Paraspeckle condensates are membraneless nuclear organelles linked to stress responses and disease states. We demonstrate that paraspeckle assembly is tightly controlled by antagonism between TDP-43 and other paraspeckle proteins, through non-random distribution of TDP-43 binding sites on the scaffolding RNA NEAT1. Structural changes in NEAT1 or altered protein stoichiometry affect condensate formation, with implications for neurodegeneration.
2026-03-27
Xiaozhou Yu, Xiao Song, Richard A. Schäfer, Qingshu Meng, Deanna Tiek, Runxin Wu, Qiu He, Maya Walker, Qi Cao, Rendong Yang, Bo Hu, Shi-Yuan Cheng
Nature Cell Biology, Published online: 27 March 2026; doi:10.1038/s41556-026-01924-w Yu et al. identify HELDR as a lncRNA co-amplified with EGFR in glioblastoma to promote a KAT7-activated malignancy programme, which can be potentially targeted with anti-EGFR therapy for improved therapeutic outcomes.
2026-03-20
Aubrey Weigel
Nature Cell Biology, Published online: 20 March 2026; doi:10.1038/s41556-026-01919-7 A study establishes a correlative light and electron microscopy workflow that reveals how individual lipid species distribute across nanoscale membrane domains, uncovering sphingomyelin sorting within the early endosome.