2026-02-19
Nilay Danış, Hüseyin Döngelli, Tarkan Ünek, Aylin Bacakoğlu, İlker Turan, Abdullah Zeki Karasu, Fulya Günşar, Elvan Işık, Muhsin Murat Harputluoglu, Kutay Sağlam, Sezai Yılmaz, Bilger Çavuş, Sabahattin Kaymakoglu, Haydar Adanır, Dinç Dinçer, Derya Arı, Meral Akdogan Kayhan, Dilara Turan Gokce, Gökhan Kabacam, Sedat Karademir, Murat Kıyıcı, Selcan Cesur, Hale Gokcan, Zeynep Melekoglu Ellik, Ramazan İdilman, Murat Dayangaç, Yasemin Balaban, Ahmet Bülent Doğrul, Hilmi Anıl Dinçer, Gupse Adalı, Feyza Dilber, Murat Taner Gulsen, Orhan Sezgin, Zekiye Nur Harput, Murat Akyıldız, Kenan Moral, Tufan Egeli, Cihan Ağalar, Mücahit Özbilgin, Mesut Akarsu
Background/Aims: De novo malignancies are an important long-term complication following liver transplantation (LT), driven by chronic immunosuppression and extended post-transplant survival. Understanding patterns by tumor type, timing, and patient characteristics is essential for optimized surveillance. This study aimed to evaluate the clinical characteristics and temporal trends of de novo neoplasms in LT recipients. Materials and Methods: A total of 6943 adult LT recipients from 16 Turkish centers were evaluated between 1999 and 2023). Two hundred eight patients with 220 histologically confirmed de novo malignancies (excluding hepatocellular carcinoma) were included. Patients who died within 30 days or developed cancer within 90 days post-LT were excluded. Incidence and mortality rates were assessed across post-transplant intervals. Results: Non-skin solid (53.2%), dermatologic (28.6%), and hematologic (18.2%) cancers were predominant. Most malignancies (76.8%) occurred within 10 years post-LT. Early-onset (<10 years) malignancies were more common in living donor recipients (62.7%, P = .001) and associated with higher mortality (39.6% vs. 11.8%, P < .001). Recipients ≤60 years exhibited a higher incidence of hematologic cancers (23.9% vs. 12.6%, P = .03) and increased mortality (39.4% vs. 27.0%, P = .05). In subgroup analysis, tacrolimus use was strongly associated with cutaneous squamous cell carcinoma (P = .004). Peak incidence occurred 2-10 years post-LT (≈13-14 per 1000 recipients), with non-skin solid tumors being the most frequent. Conclusion: De novo malignancies remain a significant long-term risk after LT, with outcomes influenced by tumor type, age, immunosuppression, and timing of onset. Risk-adapted surveillance and tailored oncologic management, particularly dermatologic screening in tacrolimus-treated patients and enhanced surveillance during the 2-10 year post-transplant period are recommended to improve long-term survival. Cite this article as: Danış N, Döngelli H, Ünek T, et al. De novo malignancies after liver transplantation: A multicenter cohort study of incidence, timing, and outcomes. Turk J Gastroenterol . 2026;37(4):510-523.
2026-02-19
Serdar Akca, Osman Cagin Buldukoglu, Galip Egemen Atar, Ayhan Hilmi Cekin
Cite this article as: Akca S, Buldukoglu OC, Atar GE, Cekin AH. Comment on machine learning–based prediction of histopathological classification in colorectal polyps. Turk J Gastroenterol . 2026;37(4):532-533.
2026-01-29
Muhammed Furkan Keser, Yahya Atayan, Mustafa Duru, Ayşe Hafsa Çağın, Zeynep Büşra Keser, Yasir Furkan Çağın
Cite this article as: Keser MF, Atayan Y, Duru M, .ağın AH, Keser ZB, .ağın YF. Upadacitinib-induced sepsis resulting in death in crohn’s disease: The first reported case. Turk J Gastroenterol. 2026;37(4):526-528.
2026-01-27
Yunus Günegül, Mukaddes Tozlu, Yunus Emre Demiral, Ahmet Tarık Eminler, Mustafa İhsan Uslan
Cite this article as: Günegül Y, Tozlu M, Demiral YE, Eminler AT, Uslan Mİ. Leukocytoclastic vasculitis occurring during upadacitinib therapy in ulcerative colitis: A case report. Turk J Gastroenterol. 2026;37(4):529-531.
2026-01-25
Xiaowei Fan, Chuyun Wang, Wei Wang, Shan Gao
Background/Aims: The present study aimed to appraise the therapeutic outcomes of cystic lesion management and the diagnostic performance of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in characterizing pelvic space-occupying lesions. Materials and Methods: EUS-FNA was performed transrectally in 83 patients with pelvic space-occupying lesions identified by ultrasonography, computed tomography, or magnetic resonance imaging (MRI) between January 2016 and December 2024. Tissue was obtained for pathological analysis and smear cytology using a 19 G or 22 G puncture needle. Cytological samples were collected, and drainage was executed for pelvic cystic lesions. In the presence of an abscess, metronidazole solution was routinely provided for irrigation. Postoperatively, additional clinical monitoring was performed to assess assess patient prognosis, including the evaluation of clinical symptoms and laboratory indicators during follow-up. Results: After pathological and/or cytological evaluation of 83 patients, 67 instances of sil solid masses were identified, comprising 41 adenocarcinomas, 6 malignant mesenchymal tumors, 7 inflammatory masses, 3 lymphomas, 2 dermoid cysts, and 8 other cases. Sixteen instances of cystic masses were recorded, comprising 3 plasma cystadenomas, alongside 13 occurrences of perirectal abscesses, of which 11 patients with perirectal abscess were drained of pus and treated with metronidazole injection. The comparison of 19G and 22G puncture needles revealed no statistically significant variation in the percentage of punctures amenable to immunohistochemistry (P > .05). Thirteen patients with perirectal abscesses exhibited variable degrees of pain during EUS-FNA. Except for one patient who exhibited hematochezia attributable to a pelvic lesion in the prostate, none of the other patients encountered postoperative complications, including fever or hematochezia. Conclusion: The EUS-FNA is a direct, secure, and minimally invasive method with therapeutic promise for clarifying the characteristics of pelvic space-occupying lesions. Cite this article as: Fan X, Wang C, Wang W, Gao S. Diagnostic value of ultrasound-guided fine-needle aspiration for pelvic space-occupying lesions via rectal endoscopic ultrasound. Turk J Gastroenterol . 2026;37(4):430-436.
2026-01-14
Melike Bektaş, Şencan Acar, Ahmet Tarık Eminler, Mukaddes Tozlu, Bilal Toka, Fuldem Mutlu, Mustafa İhsan Uslan, Erkan Parlak, Aydın Şeref Köksal
Background/Aims: Walled-off necrosis (WON) is a well-developed, enclosed accumulation of fluid, comprising a mixture of solid and liquid necrotic material, located within the pancreas and its surrounding area. Managing patients with asymptomatic WON is controversial due to limited information available about its natural history. The study aimed to determine the long-term natural course of WON in acute pancreatitis (AP) patients who remained asymptomatic and did not undergo any interventional treatment upon initial diagnosis. Materials and Methods: Acute pancreatitis patients who were followed between June 2016 and December 2019 were retrospectively evaluated. Among them, patients who developed WON after the AP attack and did not undergo any therapeutic intervention upon initial diagnosis due to their asymptomatic course were enrolled in the study. Results: The asymptomatic WON patients (n = 31) were followed up for a mean duration of 25.6 ±17.3 months. During the follow-up, 10 (32.3%) patients required interventional treatment within an average of 124.9 ± 189.5 days. Two patients died while under asymptomatic follow-up. In 12 patients (38.7%) WON disappeared; and in 7 (22.5 %) patients, mean size of the largest WON decreased from 64.7 ± 34.2 to 29.8 ± 27.4 mm. The extent of necrosis and the initial WON size were significantly higher in those requiring interventional treatment [AUC (area under the curve) were 0.844 and 0.733, respectively]. Conclusion: The management of WON usually includes close monitoring of the patient. The initial characteristics of WON (e.g., extent of necrosis, size, etc.) may aid in determining the necessity for drainage during the follow up of asymptomatic patients. Cite this article as: Bektaş M, Acar Ş, Eminler AT, et al. Natural course of asymptomatic walled-off necrosis due to acute pancreatitis. Turk J Gastroenterol. 2026;37(4):420-429.
2025-11-20
Bahri Abayli, Yeliz Simsek, Begum Seyda Avci, Adnan Kuvvetli, Akkan Avci, Cigdem Erhan
Cite this article as: Abayli B, Simsek Y, Avci BS, Kuvvetli A, Avci A, Erhan C. Successful endoscopic ethanol injection and clipping treatment of ruptured duodenal varices. Turk J Gastroenterol . 2026;37(4):524-525.