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2026-03-17
Estera Rintz, Magdalena Podlacha, Lidia Gaffke, Grażyna Jerzemowska, Zuzanna Cyske, Karolina Pierzynowska, Grzegorz Węgrzyn
Experimental & Molecular Medicine, Published online: 17 March 2026; doi:10.1038/s12276-026-01694-3 Author Correction: TFEB, FOXO3 and TLR4 in resveratrol-induced autophagy in a mucopolysaccharidosis IIIB mouse model
2026-03-13
Bo Chen, Janak L. Pathak, Xiuni Qin, Xueyang Li, Tianjiao Mao, Xi Chen, Wei Wei, Nobumoto Watanabe, Lijing Wang, Kevin H. Mayo, Jun Di, Yongliang Huo, Xiaomeng Li, Jiang Li
Experimental & Molecular Medicine, Published online: 13 March 2026; doi:10.1038/s12276-026-01671-w This study explores Sjögren’s syndrome (SjD), a condition causing dry mouth and eyes, often affecting postmenopausal women. Researchers aimed to understand why salivary gland cells malfunction in SjD. The team found that a protein called NRIP1 is overactive in these cells during SjD. They used mouse models and cell experiments to study this. NRIP1 interacts with another protein, ERα, affecting two key genes: AQP5, which helps with saliva production, and MYC, which influences cell survival and immune response. In SjD, NRIP1 reduces AQP5, leading to less saliva, and increases MYC, causing cell damage. The researchers also discovered that removing NRIP1 in mice prevented SjD symptoms. This suggests that targeting NRIP1 could be a new way to treat SjD. Future research may focus on developing therapies that adjust NRIP1 activity to improve symptoms in patients with SjD.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
2026-03-13
Justin B. Collier, Hong Soon Kang, Sara A. Grimm, Tanushree Mukherjee, Chitrangda Srivastava, Anton M. Jetten
Experimental & Molecular Medicine, Published online: 13 March 2026; doi:10.1038/s12276-026-01676-5 The study explores the role of a protein called GLIS3 in kidney function. When GLIS3 does not work properly, it can lead to a serious kidney condition called autosomal recessive polycystic kidney disease, which causes cysts in the kidneys and ultimately renal failure. Researchers found that GLIS3 is important for controlling how cells in the kidney use energy. Researchers discovered that these mice had more kidney cysts and relied more on a process called aerobic glycolysis. They used various methods, including genetic analysis and experiments with kidney cells, to study this process. They found that the protein PKM2 was more active in these mice, which might be causing the cysts to grow. By reducing PKM2 activity using a specific inhibitor, they were able to decrease the size and number of cysts in the mice.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.