2026-02-21
Şevki Hakan Eren, Mehmet Sait Menzilcioğlu, Saliha Seda Adanır, Mehmet Karadağ, İlkay Doğan, Davut Sinan Kaplan, Ayşe Aysima Özçelik, İlyas Başkonuş, Murat Akbaba, Fatih Sarı, Hamit Yıldız
Dear readers, We are pleased and honored to present the first issue of 2026 of European Journal of Therapeutics (EJT) to our readers. As the official scientific journal of Gaziantep Üniversitesi Tıp Fakültesi, we continue to pursue our mission of supporting high-quality scientific research across all fields of medicine and health sciences with determination. As a result of systematic and dedicated efforts carried out throughout the past year, our journal has significantly increased its national and international visibility and academic impact. Indeed, the continuous increase in the number of submitted and published articles reflects the growing trust and recognition of our journal. EJT is indexed in the Web of Science – Emerging Sources Citation Index under the Medicine, General & Internal category and remains one of the limited number of medical faculty journals from Türkiye included in this index [1]. In addition, the Journal Impact Factor (JIF) of 0.4 for 2024 and its placement in the Q3 quartile in both JIF and Journal Citation Indicator (JCI) rankings reflect the growing scientific influence of our journal [2]. In this issue, we aim to shed light on contemporary scientific approaches through original research from various disciplines. Our commitment to ethical principles, impartial peer-review processes, and an academic quality-oriented approach continues to be among the core values of our journal. We sincerely thank all our authors, reviewers, editors, and editorial board members whose contributions have made this success possible. We believe that by maintaining international publishing standards, we will continue to contribute to scientific knowledge in the coming years. We hope that 2026 will be a year in which scientific collaborations are strengthened, productivity is enhanced, and academic sharing increases. We extend our sincere gratitude to our valued readers and all stakeholders who contribute to our journal. Sincerely,
2026-01-23
Latif Yılmaz, İlyas Başkonuş
Objective : This study aimed to objectively define the learning curve of an experienced general surgeon transitioning to TEP repair under non-interventional mentorship and to evaluate the effect of structured supervision on operative efficiency and safety. Methods : Seventy-four male patients who underwent elective TEP repair between January 2021 and December 2024 were retrospectively analyzed. All procedures were performed by a single surgeon experienced in open and laparoscopic surgery but new to TEP repair, under real-time verbal supervision from a senior mentor who did not intervene physically. Learning progression was assessed using time-based and binary cumulative sum (CUSUM) analyses to determine thresholds for technical proficiency and surgical autonomy. Operative and postoperative outcomes were compared between the learning (cases 1–34) and proficiency (cases 35–74) phases. Results : Time-based CUSUM identified technical proficiency after approximately 34 cases, suggesting stabilization of operative performance. The mean operative time decreased significantly from 82.5 ± 21.0 minutes in the learning phase to 55.1 ± 7.9 minutes in the proficiency phase, representing a 33.2% reduction (p < 0.001). Binary CUSUM analysis indicated a transition toward predominantly autonomous performance after around 22 cases; however, mentor consultation remained appropriate in technically complex cases, even during later stages of the learning curve. The rate of peritoneal rupture declined from 35.3% to 12.5% (p = 0.027). No major complications occurred, and conversion and recurrence rates remained comparable. Conclusion : In this setting, structured, anatomy-guided verbal mentorship was associated with progressive improvements in operative efficiency and intraoperative safety during the early adoption of TEP repair by an experienced surgeon. Technical proficiency appeared to be reached after approximately 34 cases, while surgical autonomy evolved gradually rather than absolutely. These findings reflect the experience of a single surgeon–mentor pair and should be interpreted with caution; nevertheless, they suggest that non-interventional supervision may provide a safe and supportive educational framework for surgeons transitioning to TEP repair.
2026-01-21
Gökçe Keçeci, Zehra Güner, Süleyman Ziya Şenyurt, Kamile Erciyas
Objective : The aim of this study is to comparatively evaluate how the color stability of different esthetic composite resins and natural anterior teeth is affected after exposure to thermal aging and various mouthrinse solutions. Materials and Methods : A total of 96 extracted permanent anterior teeth were prepared with Class V cavities on the buccal surfaces and restored using three different esthetic composite resins: G-aenial Anterior (GC Corp., Tokyo, Japan), SOLARE X (GC Corp., Tokyo, Japan), and Estelite Sigma Quick (Tokuyama Dental Corp., Tokyo, Japan). The palatal surfaces of the same teeth were used as a natural enamel reference. Following restoration, all specimens underwent thermal aging for 10,000 cycles between 5 °C and 55 °C. Subsequently, the samples were immersed for 24 hours in four different mouthrinse solutions: 0.12% chlorhexidine solution (Kloroben, Drogsan, Türkiye), an antiseptic and anticavity formulation (Listerine Total Care, Johnson & Johnson, USA), a zinc-containing mouthrinse (Listerine Total Care Stay White, Johnson & Johnson, UK), and distilled water (control group). Color measurements were performed using a VITA Easyshade Advance 4.0 spectrophotometer, and color differences were calculated according to the CIEDE2000 (ΔE₀₀) formula. Results : Color changes were observed in all composite materials after thermal aging and exposure to mouth-rinse solutions. Specimens exposed to chlorhexidine-containing solutions exhibited significantly greater discoloration compared with the control group (p < 0.050). Statistically significant differences in color stability were also found among the materials (p < 0.050). Conclusion : Within the limitations of this in vitro study, chlorhexidine-containing mouthrinse caused the highest color change, while material type significantly influenced color stability.
2025-12-07
Ece Kaplan Doğan
Objective : This study aimed to determine the effect of nursing students’ fertility health knowledge levels on their awareness of healthy living. Methods : A descriptive study design was employed. The research was conducted with 453 students enrolled in the Nursing Department of the Faculty of Health Sciences at Gaziantep University during the 2023–2024 academic year. Data were collected using a Personal Information Form, the Fertility Health Knowledge Scale (FHKS), and the Healthy Life Awareness Scale (HLAS). Data analysis included Student’s t-test, one-way ANOVA, correlation, and regression analyses. Results : The students’ mean total score on the FHKS was 109.29 ± 13.30. Their mean total HLAS score was 55.17 ± 10.05, with sub-dimension scores of 19.26 ± 3.70 for change, 14.43 ± 3.43 for socialization, 11.28 ± 2.44 for responsibility, and 10.19 ± 2.73 for nutrition. A weak but statistically significant positive correlation was found between total FHKS and HLAS scores (r = 0.389, p = 0.001). Fertility health knowledge levels explained 15% of the variance in healthy living awareness scores (F = 80.436; p = 0.001). Conclusion : Nursing students demonstrated high levels of fertility health knowledge and healthy living awareness. Furthermore, an increase in fertility health knowledge was associated with a corresponding increase in awareness of healthy living.
2025-11-30
Ömer Faruk Bucak, Adil Öncel, Merve Çalkın Korkmaz, Sena Tolu
Objective : Altered sagittal spinopelvic alignment may influence lower extremity joint loading, yet its relationship with femoral cartilage morphology in knee osteoarthritis (KOA) remains unclear. This study aimed to investigate the association between sagittal spinopelvic parameters and femoral cartilage thickness in individuals with symptomatic KOA using high-resolution ultrasonography (USG). Methods : A total of 87 patients with symptomatic KOA, diagnosed per American College of Rheumatology criteria, were prospectively evaluated. Spinopelvic parameters—including pelvic incidence (PI), lumbar lordosis (LL), and PI–LL mismatch—were measured via lateral standing radiographs. Femoral cartilage thickness at the medial, intercondylar, and lateral compartments was assessed bilaterally using standardized musculoskeletal USG. Correlations were analyzed using Pearson’s test and multivariate linear regression, with subgroup analysis based on PI–LL mismatch thresholds. Results : PI–LL mismatch showed a weak negative correlation only with right intercondylar femoral cartilage thickness (r = –0.203, p = 0.044), while no significant correlations were found with medial or lateral compartments (all p > 0.050). Multivariate regression analysis confirmed LL as an independent predictor of left medial femoral cartilage thickness (p = 0.042), accounting for 7.8% of the variance. Each one-degree increase in LL was associated with a 0.012 millimeter increase in medial femoral cartilage thickness of the left knee. No significant associations were found between PI or LL alone and cartilage thickness in other compartments. Conclusion : Increased PI–LL mismatch is associated with focal femoral cartilage thinning in KOA. These findings suggest that sagittal imbalance may affect joint morphology distal to the spine. Combined assessment of spinopelvic alignment and ultrasonographic cartilage thickness may offer added value in early-stage KOA evaluation and biomechanical risk stratification.
2025-11-30
Bahri Bozgeyik, Çağrı Karabulut, Sezgin Bahadır Tekin, Savaş Güner
Objective : Our aim in this study was to evaluate the effect of double plate fixation method on the results of acetabulum anterior column fractures. Methods : The data of patients who were operated with the stoppa approach for isolated anterior acetabular colon fracture in our department were analyzed. The patients were divided into two groups according to the fixation method as single plate and double plate patients. The two groups were compared in terms of clinical and functional outcomes. Statistical analysis was performed using the Mann-Whitney U test and Chi-square test, with a significance threshold of p<0.05. Results : Forty eight patients who met the study criteria were included in the study. Twenty four patients with single plate fixation were determined as Group 1 and 24 patients with double plate fixation were determined as Group 2. There was no statistically significant difference between the groups in terms of intraoperative blood loss, surgical time, and Harris hip scores (P>0.05). Conlusions : Clinical and functional outcomes were similar in both groups. Therefore, the methods are not superior to each other.
2025-11-26
Halime Tuba Canbaz, Hilal Arslan, Seda Çetinkaya Karabekir
Objective: Cisplatin (CIS) is a frequently used chemotherapeutic drug; nevertheless, its clinical efficacy is limited by cardiotoxicity, mostly due to oxidative stress and apoptosis. Natural antioxidants such as S-Allyl-L-Cysteine (SAC) and Allyl Disulfide (ADS)—organosulfur compounds derived from garlic—exhibit potential in mitigating such damage. This study aimed to evaluate CIS-induced cardiotoxicity in rats and investigate the potential for SAC and ADS to reduce this toxicity. Methods: Four groups -Control, CIS, CIS + SAC, and CIS + ADS- were randomly assigned to thirty-two female Sprague Dawley rats. On days 1 and 8 of the experiment, CIS was given intraperitoneally at a dose of 5 mg/kg, and for 14 days in a row, SAC and ADS were given orally by gavage at a dose of 100 mg/kg. Using Hematoxylin-Eosin (H&E) and Periodic Acid-Schiff (PAS) staining, heart tissues were excised at the termination of the experiment and examined histopathologically. Results: In the CIS group, prominent histopathological changes, including interstitial congestion, lymphocytic infiltration, edema, and vacuolar degeneration in cardiomyocytes, were observed. PAS staining showed glycoprotein accumulation and chondromatous metaplasia. All these changes were reversed in either the CIS+SAC group or the CIS+ADS group by improving cardiac architecture and lowering levels of congestion, edema, and degeneration. Conclusion: This study shows that SAC and ADS have protective effects against CIS-induced cardiotoxicity. These natural antioxidants may be used to prevent cardiotoxicity that is induced by chemotherapy.
2025-10-29
Nazif Yalçın, Nizameddin Koca
Objective : Cardiometabolic indices, including the plasma atherogenic index (PAI) and triglyceride-glucose (TyG) index, are emerging markers for diabetic complications. However, their associations in type 1 diabetes mellitus (T1DM) remain underexplored. This study aimed to evaluate the associations between standardized PAI and TyG indices and diabetic nephropathy (DN) and coronary artery disease (CAD) in T1DM patients. Methods : This cross-sectional study included 114 adults with T1DM. DN and CAD were diagnosed based on standard clinical criteria. PAI and TyG indices were calculated and standardized (z-score adjusted). Penalized logistic regression (LASSO) was employed to identify independent correlates. Model performance was assessed using receiver operating characteristic (ROC) curves and area under the curve (AUC). Results : DN and CAD prevalences were 40.4% and 17.5%, respectively. The standardized TyG index independently predicted DN (OR = 20.20, p<0.001), whereas standardized PAI independently associated with CAD (OR = 6.71, p=0.016). Age was also significantly associated with increased CAD risk (OR = 1.07, p=0.033). ROC analyses demonstrated excellent discriminative capabilities, with AUC values of 0.94 for DN and 0.87 for CAD after internal validation. Conclusion : The standardized TyG index is an effective predictor for DN, and standardized PAI is strongly predictive of CAD in T1DM patients. While these simple indices may hold promise for early risk stratification, the findings should be interpreted with caution due to the modest sample size and cross-sectional design. External validation in larger, prospective cohorts is required before clinical application.