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2026-07-23
Elisa Martini
Nature Cardiovascular Research, Published online: 23 July 2026; doi:10.1038/s44161-026-00857-9 Cardiac mechanical loading inhibits tumor cell proliferation]]>
DOI: 10.1038/s44161-026-00857-92026-07-23
Alexander J. F. Thurston
Nature Cardiovascular Research, Published online: 23 July 2026; doi:10.1038/s44161-026-00848-w Myocardial infarction can cause lasting cardiac damage, heart failure and death, and immune responses are increasingly recognized as key determinants of outcomes. A study now shows that ST-segment elevation myocardial infarction (STEMI) mobilizes immature neutrophil progenitors from the bone marrow, predicting increased mortality risk.]]>
DOI: 10.1038/s44161-026-00848-w2026-07-07
Laura Sen-Martín
Nature Cardiovascular Research, Published online: 07 July 2026; doi:10.1038/s44161-026-00833-3 Sen-Martín et al. demonstrate that mavacamten exerts therapeutic benefit in hypertrophic cardiomyopathy caused by both missense and truncating MYBPC3 variants by reducing hypercontractility and myocardial remodeling through normalization of myosin activity.]]>
DOI: 10.1038/s44161-026-00833-32026-07-07
Luca Saba
Nature Cardiovascular Research, Published online: 07 July 2026; doi:10.1038/s44161-026-00832-4 Saba and Narula review the causes and consequences of the heterogeneous manifestations of atherosclerosis across vascular beds and share their perspective on vascular calcification as a readout of the underlying processes, with clinical implications for diagnosis and management.]]>
DOI: 10.1038/s44161-026-00832-42026-07-03
Mathis Richter
Nature Cardiovascular Research, Published online: 03 July 2026; doi:10.1038/s44161-026-00836-0 Richter et al. show that the mobilization of neutrophil progenitors assessed from routine blood tests can predict 30-day mortality in patients following ST-elevation myocardial infarction and enable rapid risk stratification.]]>
DOI: 10.1038/s44161-026-00836-02026-06-24
Elisa Martini
Nature Cardiovascular Research, Published online: 24 June 2026; doi:10.1038/s44161-026-00840-4 Interim results of the Heart-2 clinical trial testing the safety and efficacy of VERVE-102 therapy]]>
DOI: 10.1038/s44161-026-00840-42026-06-22
Ankit Sinha
Nature Cardiovascular Research, Published online: 22 June 2026; doi:10.1038/s44161-026-00827-1 Atherosclerotic plaque rupture underlies many cerebrovascular events, yet the molecular determinants of vulnerable plaque morphology remain poorly defined. Using histomorphology-guided spatial proteomics of 112 carotid plaques, Sinha et al. show that cap thickness-associated molecular programs are spatially confined to the fibrous cap and necrotic core, link thin-cap plaques to inflammatory and lipid handling pathways, and identify PCSK9 as a compartment-specific marker induced by oxidative and inflammatory stress in vascular smooth muscle cells.]]>
DOI: 10.1038/s44161-026-00827-12026-06-04
Andrea Tavosanis
Nature Cardiovascular Research, Published online: 04 June 2026; doi:10.1038/s44161-026-00830-6 A world of possibilities for cardiac simulations]]>
DOI: 10.1038/s44161-026-00830-62026-05-29
Mark Atallah
Nature Cardiovascular Research, Published online: 29 May 2026; doi:10.1038/s44161-026-00821-7 Atallah et al. show that oxidized phospholipids and lipoprotein (a), but not systemic inflammation indicators are associated with tissue-level myocardial inflammation after infarction.]]>
DOI: 10.1038/s44161-026-00821-72026-05-21
Nature Cardiovascular Research, Published online: 21 May 2026; doi:10.1038/s44161-026-00826-2 Pathogenic variants in RBM20, which encodes a cardiac splicing factor, lead to an aggressive form of dilated cardiomyopathy with a high risk of ventricular arrhythmias. This study shows that genetic or pharmacological inhibition of CAMK2D, one of the RBM20 splicing targets, rescues cardiac dysfunction in mouse models of RBM20.]]>
DOI: 10.1038/s44161-026-00826-22026-04-01
Andrea Tavosanis
Nature Cardiovascular Research, Published online: 01 April 2026; doi:10.1038/s44161-026-00809-3 LIFE-Preserved enables long-term risk prediction in patients with heart failure with preserved ejection fraction
2026-03-17
Mostafa A. Al-Alusi
Nature Cardiovascular Research, Published online: 17 March 2026; doi:10.1038/s44161-026-00780-z Deep learning can identify cardiac abnormalities from echocardiogram videos, but previous work has predominantly used 2D video clips from a single cross-section of the heart. Research now shows that more complex approaches that integrate information from several echocardiographic views can improve deep learning prediction of cardiac abnormalities.
2026-03-17
Guillaume Baudry, Prashanth Kulkarni, Tor Biering-Sørensen, Adam D. DeVore, Charles Michael Gibson, Christopher B. Granger, Harriette G. C. Van Spall
Nature Cardiovascular Research, Published online: 17 March 2026; doi:10.1038/s44161-026-00788-5 Baudry et al. review the main components and operational considerations for running decentralized clinical trials, outline their specific advantages for the cardiovascular field, and propose strategies to mitigate their downsides and ensure their quality.
2026-03-12
David Smyth, Liyong Zhang, Mohammad Al-Khalaf, Sabrina Robichaud, Richard Seymour, Michele Geoffrion, Richard Jung, Simon Parlow, Feng Du, Brian McNeill, Qiujiang Du, Caroline Beauregard, Xiaoling Zhao, Mireille Ouimet, Shawn T. Beug, Eric C. LaCasse, Katey J. Rayner, Tak W. Mak, Benjamin Hibbert, Robert G. Korneluk, Peter P. Liu
Nature Cardiovascular Research, Published online: 12 March 2026; doi:10.1038/s44161-026-00782-x Smyth et al. demonstrate that a cellular inhibitor of apoptosis, cIAP2, exacerbates inflammation and cardiac injury after myocardial infarction and that its inhibition, either genetically or via Smac mimetics, offers a promising immunotherapeutic strategy to reduce post-MI damage and progression to heart failure.
2026-03-09
Gerburg Schwaerzer
Nature Cardiovascular Research, Published online: 09 March 2026; doi:10.1038/s44161-026-00795-6 Leptin’s path to cardioprotection goes through fat from brain to heart