2026-10-15
Mostafa A. Al-Alusi, Kavya Kopparapu, Pulkit Singh, Paolo di Achille, Christopher Reeder, Emily S. Lau, Tal Shnitzer, Carl T. Andrews, Shinwan Kany, Joel T. Rämö, Julian S. Haimovich, Shaan Khurshid, Michael H. Picard, Jennifer E. Ho, Puneet Batra, Mahnaz Maddah, Steven A. Lubitz, Patrick T. Ellinor
Al-Alusi et al. develop DROID-RV, a deep learning model to assess right ventricular dilation and dysfunction, and show that the model’s predictions are associated with mortality and cardiovascular disease risk.
DOI: 10.1038/s44161-026-00886-42026-10-13
Sarra Harrabi, Yichen Wu, Omar Majwal, Gabriel Asslo, George Azar, Geoffrey H. Tison, Minhaj Ansari, Milos Vukadinovic, David Ouyang, Joshua P. Barrios, Jacques Delfrate, Robert Avram
Harrabi et al. develop DeepCORO-CLIP, a multiview video–text model, to interpret coronary angiograms by detecting obstructive stenosis and predict 1-year cardiovascular events.
DOI: 10.1038/s44161-026-00890-82026-10-09
Ivan A. Kuznetsov, Kristina Li, Yasmine Guedira, Bridget Simonson, Mark Chaffin, Yonathan T. Aberra, Kenneth C. Bedi Jr., Trace Thome, Yijun Yang, Kirsten Branch, Wencao Zhao, Wenkai Zhu, Wei Zhou, Farid F. Kadyrov, Junedh M. Amrute, Ling Lai, Joanna Griffin, Li Li, Jian Li, Shelley D. Miyamoto, Patrick Ellinor, Kenneth B. Margulies, Kory J. Lavine, Zoltan Arany, Jonathan J. Edwards
Kuznetsov et al. present a multi-modal transcriptomic atlas of the human right ventricle, revealing a two-phase progression from pressure loading to failure, with erosion of tissue-protective programs preceding focal fibrotic and vascular remodeling.
DOI: 10.1038/s44161-026-00885-52026-10-01
Andrea Tavosanis
DOI: 10.1038/s44161-026-00893-52026-10-01
Qianyi Li, Ziang Li, Xiaoyu Zhang, Hakan Akgun, Swetika Chaturvedi, Hooi Khee Teo, Kamalesh Anbalakan, David Sim, Kenneth Michael Chew Yun Chi, Kee Thai Yeo, Derek John Hausenloy, Tural Khudiyev
Li et al. develop an all-fiber garment capable of wireless and remote monitoring of cardiopulmonary sounds in adults and neonates.
DOI: 10.1038/s44161-026-00882-82026-09-28
Rosemary B. Kirk, Celine F. Santiago, Hugh Watkins, Christopher N. Toepfer
Inherited cardiomyopathies caused by haploinsufficiency are promising targets for therapies that restore endogenous gene expression. In this Review, Kirk et al. discuss emerging gene upregulation strategies, evaluate their mechanisms, therapeutic potential and challenges for preventing disease progression.
DOI: 10.1038/s44161-026-00884-62026-09-28
Yi Fan, Dakota J. Nuttall, Yi Zhao, Dina Abbasian, Clarissa Shoffler, Christopher Petucci, Wyatt G. Paltzer, Yu-Ling Chang, James Marchant, Diana Presas-Ramos, Kai P. Atlass, Stephen A. Nemr, Jiyoung Bae, Sanjeev S. Ranade, Alexandre R. Colas, Xiao Li, James F. Martin, Ahmed I. Mahmoud
Using integrated multiomics and cell-specific genetic models, Fan et al. reveal how succinate dehydrogenase inhibition promotes multicellular cardiac repair after myocardial infarction through coordinated metabolic and epigenetic reprogramming, while defining distinct contributions of cardiomyocytes and myofibroblasts to this response.
DOI: 10.1038/s44161-026-00881-92026-09-25
Alicia Lundby
Proteomic profiling of 149 explanted human hearts shows that, in end-stage heart failure, protein profiles converge across etiologies. Proteome profiles indicate that molecular subtyping, rather than clinical phenotyping, may better capture patient heterogeneity.
DOI: 10.1038/s44161-026-00875-72026-07-23
Elisa Martini
Nature Cardiovascular Research, Published online: 23 July 2026; doi:10.1038/s44161-026-00857-9 Cardiac mechanical loading inhibits tumor cell proliferation]]>
DOI: 10.1038/s44161-026-00857-92026-07-23
Alexander J. F. Thurston
Nature Cardiovascular Research, Published online: 23 July 2026; doi:10.1038/s44161-026-00848-w Myocardial infarction can cause lasting cardiac damage, heart failure and death, and immune responses are increasingly recognized as key determinants of outcomes. A study now shows that ST-segment elevation myocardial infarction (STEMI) mobilizes immature neutrophil progenitors from the bone marrow, predicting increased mortality risk.]]>
DOI: 10.1038/s44161-026-00848-w2026-07-07
Laura Sen-Martín
Nature Cardiovascular Research, Published online: 07 July 2026; doi:10.1038/s44161-026-00833-3 Sen-Martín et al. demonstrate that mavacamten exerts therapeutic benefit in hypertrophic cardiomyopathy caused by both missense and truncating MYBPC3 variants by reducing hypercontractility and myocardial remodeling through normalization of myosin activity.]]>
DOI: 10.1038/s44161-026-00833-32026-07-07
Luca Saba
Nature Cardiovascular Research, Published online: 07 July 2026; doi:10.1038/s44161-026-00832-4 Saba and Narula review the causes and consequences of the heterogeneous manifestations of atherosclerosis across vascular beds and share their perspective on vascular calcification as a readout of the underlying processes, with clinical implications for diagnosis and management.]]>
DOI: 10.1038/s44161-026-00832-42026-07-03
Mathis Richter
Nature Cardiovascular Research, Published online: 03 July 2026; doi:10.1038/s44161-026-00836-0 Richter et al. show that the mobilization of neutrophil progenitors assessed from routine blood tests can predict 30-day mortality in patients following ST-elevation myocardial infarction and enable rapid risk stratification.]]>
DOI: 10.1038/s44161-026-00836-02026-06-24
Elisa Martini
Nature Cardiovascular Research, Published online: 24 June 2026; doi:10.1038/s44161-026-00840-4 Interim results of the Heart-2 clinical trial testing the safety and efficacy of VERVE-102 therapy]]>
DOI: 10.1038/s44161-026-00840-42026-06-22
Ankit Sinha
Nature Cardiovascular Research, Published online: 22 June 2026; doi:10.1038/s44161-026-00827-1 Atherosclerotic plaque rupture underlies many cerebrovascular events, yet the molecular determinants of vulnerable plaque morphology remain poorly defined. Using histomorphology-guided spatial proteomics of 112 carotid plaques, Sinha et al. show that cap thickness-associated molecular programs are spatially confined to the fibrous cap and necrotic core, link thin-cap plaques to inflammatory and lipid handling pathways, and identify PCSK9 as a compartment-specific marker induced by oxidative and inflammatory stress in vascular smooth muscle cells.]]>
DOI: 10.1038/s44161-026-00827-12026-06-04
Andrea Tavosanis
Nature Cardiovascular Research, Published online: 04 June 2026; doi:10.1038/s44161-026-00830-6 A world of possibilities for cardiac simulations]]>
DOI: 10.1038/s44161-026-00830-62026-05-29
Mark Atallah
Nature Cardiovascular Research, Published online: 29 May 2026; doi:10.1038/s44161-026-00821-7 Atallah et al. show that oxidized phospholipids and lipoprotein (a), but not systemic inflammation indicators are associated with tissue-level myocardial inflammation after infarction.]]>
DOI: 10.1038/s44161-026-00821-72026-05-21
Nature Cardiovascular Research, Published online: 21 May 2026; doi:10.1038/s44161-026-00826-2 Pathogenic variants in RBM20, which encodes a cardiac splicing factor, lead to an aggressive form of dilated cardiomyopathy with a high risk of ventricular arrhythmias. This study shows that genetic or pharmacological inhibition of CAMK2D, one of the RBM20 splicing targets, rescues cardiac dysfunction in mouse models of RBM20.]]>
DOI: 10.1038/s44161-026-00826-22026-04-01
Andrea Tavosanis
Nature Cardiovascular Research, Published online: 01 April 2026; doi:10.1038/s44161-026-00809-3 LIFE-Preserved enables long-term risk prediction in patients with heart failure with preserved ejection fraction
2026-03-17
Mostafa A. Al-Alusi
Nature Cardiovascular Research, Published online: 17 March 2026; doi:10.1038/s44161-026-00780-z Deep learning can identify cardiac abnormalities from echocardiogram videos, but previous work has predominantly used 2D video clips from a single cross-section of the heart. Research now shows that more complex approaches that integrate information from several echocardiographic views can improve deep learning prediction of cardiac abnormalities.
2026-03-17
Guillaume Baudry, Prashanth Kulkarni, Tor Biering-Sørensen, Adam D. DeVore, Charles Michael Gibson, Christopher B. Granger, Harriette G. C. Van Spall
Nature Cardiovascular Research, Published online: 17 March 2026; doi:10.1038/s44161-026-00788-5 Baudry et al. review the main components and operational considerations for running decentralized clinical trials, outline their specific advantages for the cardiovascular field, and propose strategies to mitigate their downsides and ensure their quality.
2026-03-12
David Smyth, Liyong Zhang, Mohammad Al-Khalaf, Sabrina Robichaud, Richard Seymour, Michele Geoffrion, Richard Jung, Simon Parlow, Feng Du, Brian McNeill, Qiujiang Du, Caroline Beauregard, Xiaoling Zhao, Mireille Ouimet, Shawn T. Beug, Eric C. LaCasse, Katey J. Rayner, Tak W. Mak, Benjamin Hibbert, Robert G. Korneluk, Peter P. Liu
Nature Cardiovascular Research, Published online: 12 March 2026; doi:10.1038/s44161-026-00782-x Smyth et al. demonstrate that a cellular inhibitor of apoptosis, cIAP2, exacerbates inflammation and cardiac injury after myocardial infarction and that its inhibition, either genetically or via Smac mimetics, offers a promising immunotherapeutic strategy to reduce post-MI damage and progression to heart failure.
2026-03-09
Gerburg Schwaerzer
Nature Cardiovascular Research, Published online: 09 March 2026; doi:10.1038/s44161-026-00795-6 Leptin’s path to cardioprotection goes through fat from brain to heart