Glymphatic dysfunction: a unifying hypothesis for delirium
2026-03-30
Hans Christian Boesen, Ting Du, Steven A. Goldman, Maiken Nedergaard
Nature Reviews Neurology, Published online: 30 March 2026; doi:10.1038/s41582-026-01194-y Delirium presents a major challenge in intensive care and postoperative settings; however, the pathophysiology is poorly understood. In this Perspective, Nedergaard and colleagues examine the evidence for impaired glymphatic flow as a central mechanism in the development of delirium and discuss potential strategies to mitigate delirium risk.