2026-10-19
Zirui Fan, Bingxin Zhao
This article provides an overview of brain-focused multi-organ imaging genetics, outlining key data resources and analytical frameworks and reviewing cross-organ genetic insights into brain diseases. The authors propose a roadmap for implementing agentic AI co-scientists as essential infrastructure for advancing an integrated, whole-body understanding of brain health and disease.
DOI: 10.1038/s41582-026-01276-x2026-10-09
Ian Fyfe
Tunnelling nanotubes enable mitochondria to be transferred between glioblastoma cells and astrocytes, new research has shown.
DOI: 10.1038/s41582-026-01281-02026-10-09
Lisa Kiani
Proteomic changes associated with menopause track with cognitive ageing and dementia risk, according to new research.
DOI: 10.1038/s41582-026-01278-92026-10-09
Lisa Kiani
Sleep abnormalities progressively worsen during the premanifest phase of amyotrophic lateral sclerosis, new research shows.
DOI: 10.1038/s41582-026-01279-82026-10-09
Lisa Kiani
The pre-relapse immune signature in people with multiple sclerosis (MS) is enriched for Epstein−Barr virus (EBV)-responsive host genes, according to a new study.
DOI: 10.1038/s41582-026-01280-12026-10-06
Steffen Tiedt, Naomi Vlegels, Konstantinos Dimitriadis, Wenlu Li, Glen C. Jickling, Louise D. McCullough, Arthur Liesz, Eng H. Lo, Michael D. Hill
Clinical decision-making in ischaemic stroke relies mainly on examination and imaging, which offer limited insight into underlying molecular mechanisms. Here, the authors propose a six-phase roadmap for bringing molecular biomarkers into clinical practice, focusing on establishing context of use, assay development, clinical validation and biomarker-guided trials.
DOI: 10.1038/s41582-026-01270-32026-09-29
Sarah M. Brooker, Robert Coukos, Dimitri Krainc
Exploration of the underlying genetic causes of neurodegenerative disorders has revealed defects in endolysosomal pathways as crucial contributors to neuronal dysfunction and death. This Review provides an overview of mechanisms of lysosomal dysfunction in neurodegenerative disease, focusing particularly on Parkinson disease, Alzheimer disease, frontotemporal dementia and amyotrophic lateral sclerosis.
DOI: 10.1038/s41582-026-01262-32026-09-28
Rosa Cortese, Yael Hacohen, Georgina Arrambide, Alessia Bianchi, Gabriele DeLuca, Massimo Filippi, Claudio Gasperini, Ruth Geraldes, Cristina Granziera, Lukas Haider, Silvia Messina, Jaume Sastre-Garriga, Paolo Preziosa, Maria Assunta Rocca, Àlex Rovira, Mar Tintoré, Ahmed Toosy, Carla Tortorella, Manuela Vaneckova, Tarek Yousry, Jacqueline Palace, Nicola De Stefano, Frederik Barkhof, Olga Ciccarelli, Christian Enzinger, Deborah Pareto, Menno Schoonheim
This Expert Recommendation, on behalf of the Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) study group, provides recommendations for the practical use of conventional and non-conventional MRI for diagnosis, monitoring and research in aquaporin 4-positive neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease.
DOI: 10.1038/s41582-026-01271-22026-03-30
Hans Christian Boesen, Ting Du, Steven A. Goldman, Maiken Nedergaard
Nature Reviews Neurology, Published online: 30 March 2026; doi:10.1038/s41582-026-01194-y Delirium presents a major challenge in intensive care and postoperative settings; however, the pathophysiology is poorly understood. In this Perspective, Nedergaard and colleagues examine the evidence for impaired glymphatic flow as a central mechanism in the development of delirium and discuss potential strategies to mitigate delirium risk.
2026-03-16
Emrah Düzel, Michael R. Kreutz
Nature Reviews Neurology, Published online: 16 March 2026; doi:10.1038/s41582-026-01189-9 Impairment of episodic memory — the ability to recollect personal experiences — is an early symptom of Alzheimer disease (AD) and profoundly affects life participation and independence. This Review introduces the circuit utilization framework, which posits that episodic memory impairment in AD includes a regainable component stemming from suboptimal utilization of brain circuits.