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NATURE REVIEWS DRUG DISCOVERY

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8 parsed articles

Last update: 2026-09-21

Latest articles

A translational framework for extrahepatic oligonucleotide delivery

2026-09-09

Łukasz Jan Kiełpiński, Felix Franz Schumacher

To unlock the ‘plug-and-play’ potential of extrahepatic delivery of oligonucleotide-based drugs, the field must bridge the gap between preclinical promise and clinical reality. Here, we outline an industry-grade quality framework to eliminate methodological artifacts and ensure the translational and commercial viability of novel platforms.

DOI: 10.1038/d41573-026-00125-2